420355
Isoprenaline hydrochloride
≥99% (TLC), solid, β-adrenoceptor agonist, Calbiochem
别名:
盐酸异丙肾上腺素
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关于此项目
经验公式（希尔记法）:
C11H17NO3 · xHCl
化学文摘社编号:
分子量:
211.26 (free base basis)
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥99% (TLC)
Form:
solid
Storage condition:
OK to freeze, protect from light
产品名称
盐酸异丙肾上腺素, Phenethylamine derivative.
description
Merck USA index - 14, 5217
Quality Segment
assay
≥99% (TLC)
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
white to off-white, white
solubility
ethanol: soluble, water: soluble
shipped in
ambient
storage temp.
10-30°C
SMILES string
[Cl-].N(C(C)C)CC(O)c1cc(c(cc1)O)O.[H+]
InChI
1S/C11H17NO3.ClH/c1-7(2)12-6-11(15)8-3-4-9(13)10(14)5-8;/h3-5,7,11-15H,6H2,1-2H3;1H
InChI key
IROWCYIEJAOFOW-UHFFFAOYSA-N
General description
苯乙胺衍生物。一种刺激腺苷酸环化酶活性的选择性β-肾上腺素能激动剂。促进糖原分解并引起支气管扩张。通过产生一氧化氮增加兔气管细胞中Cl–的扩散和电位差。据报道，通过Rap1和B-Raf依赖性过程激活MAP激酶（ERK）。
Biochem/physiol Actions
主要靶标
β肾上腺素能激动剂
β肾上腺素能激动剂
产物不与ATP竞争。
可逆：否
细胞渗透性：否
Preparation Note
溶液中不稳定；仅在使用前进行复溶。
Other Notes
Schmitt, J.M., and Stork, P.J.2000.J. Biol. Chem.275, 25342.
Carmena, M.J., et al. 1997.Prostate 33, 46.
Takemura, H., et al. 1995.J. Pharmacol.Exp.Ther.274, 584.
Kishimoto, I., et al. 1994.J. Biol. Chem.269, 28300.
Macaulay, S.L., et al. 1994.Mol.Cell Biochem.141, 27.
Yashiro, K., et al. 1994.J. Biochem.115, 1040.
Ladenheim, R.G., et al. 1993.J. Neurochem.60, 260.
von Zastrow, M., et al. 1993.J. Biol. Chem.268, 763.
Mokhtari, A., et al. 1985.J. Cyclic Nucleotide Protein Phosphorylation Res.10, 213.
Carmena, M.J., et al. 1997.Prostate 33, 46.
Takemura, H., et al. 1995.J. Pharmacol.Exp.Ther.274, 584.
Kishimoto, I., et al. 1994.J. Biol. Chem.269, 28300.
Macaulay, S.L., et al. 1994.Mol.Cell Biochem.141, 27.
Yashiro, K., et al. 1994.J. Biochem.115, 1040.
Ladenheim, R.G., et al. 1993.J. Neurochem.60, 260.
von Zastrow, M., et al. 1993.J. Biol. Chem.268, 763.
Mokhtari, A., et al. 1985.J. Cyclic Nucleotide Protein Phosphorylation Res.10, 213.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：刺激性（B）
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
No data available
flash_point_c
No data available