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Merck
CN

5.00299

烟酰胺

EMPROVE® ESSENTIAL, Ph. Eur., BP, JP, USP, FCC

别名:

Nicotinamide, Nicotinamide, Niacinamide, 3-Pyridinecarboxamide

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关于此项目

经验公式（希尔记法）:
C6H6N2O
化学文摘社编号:
98-92-0
分子量:
122.12
UNSPSC Code:
12352111
EC Index Number:
202-713-4
MDL number:
MFCD00006395

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SMILES string

NC(=O)c1cnccc1

InChI

1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9)

InChI key

DFPAKSUCGFBDDF-UHFFFAOYSA-N

agency

BP, JP, Ph. Eur., USP

reg. compliance

FCC

description

EMPROVE® ESSENTIAL Ph Eur,BP,USP,JP,FCC

product line

EMPROVE® ESSENTIAL

form

solid

autoignition temp.

480 °C

potency

3530-3540 mg/kg LD50, oral (Rat), >2000 mg/kg LD50, skin (Rabbit)

technique(s)

API processing | cocrystal formation: suitable

pH

6.0-7.5 (20 °C, 50 g/L in H2O)

bp

150-160 °C/0.0007 hPa

mp

128-131 °C (sublimed)

transition temp

flash point 182 °C

density

1.40 g/cm3 at 20 °C

application(s)

liquid formulation
pharmaceutical
solid formulation

storage temp.

15-25°C

Quality Level

500

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相关类别

General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Nicotinamide is a commonly used ingredient in food and pharmaceutical applications. In pharmaceutical formulations, nicotinamide has been used for a range of different dosage forms.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H319

Hazard Classifications

Eye Irrit. 2

存储类别

11 - Combustible Solids

wgk

WGK 1

flash_point_f

302.0 °F - closed cup

flash_point_c

150 °C - closed cup

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商品

Improving API Solubility using API Processing

Instead of addressing API solubility during formulation, tackle it early during development. Read about the various methods for API processing.

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