5.05227
(-)-Cytisine
别名:
(-)-Cytisine, nAChR Agonist, (-)-Cytisine, Nicotinic Acetylcholine Receptor Agonist, (-)-Cytisine, Baptitoxine, Sophorine
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关于此项目
经验公式（希尔记法）:
C11H14N2O
化学文摘社编号:
分子量:
190.24
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥99% (HPLC)
Form:
solid
Storage condition:
OK to freeze, protect from light
assay
≥99% (HPLC)
Quality Segment
form
solid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, protect from light
color
pale yellow
solubility
water: 100 mM
storage temp.
2-8°C
SMILES string
N21C[C@@H]3CNC[C@H](C3)C2=CC=CC1=O
InChI
1S/C11H14N2O/c14-11-3-1-2-10-9-4-8(5-12-6-9)7-13(10)11/h1-3,8-9,12H,4-7H2/t8-,9-/m0/s1
InChI key
ANJTVLIZGCUXLD-IUCAKERBSA-N
General description
A potent agonist selective for neuronal nAChRs (Ki = 2, 5890, 480, 329, and 492 nM at α4β2, α7, α3β4, α6/α4β4, α1β1γδ, respectively). Clinically used as a smoking cessation medicine and often used in addiction studies.
Biochem/physiol Actions
Primary Target
nAChR
nAChR
Reversible: yes
Target Ki: 2, 5890, 480, 329, and 492 nM at &alpha
Preparation Note
Following reconstitution, aliquot and freeze (-20°C. Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Chen, Y., et al., 2012. Br J Pharmacol.165, 1006.
West, R., 2011, N. Engl. J. Med.365, 1193.
Happe, K., et al., 1994. Neurosci.62, 929.
Reavill, C. et al., 1990. Neuropharmacol.29, 619.
West, R., 2011, N. Engl. J. Med.365, 1193.
Happe, K., et al., 1994. Neurosci.62, 929.
Reavill, C. et al., 1990. Neuropharmacol.29, 619.
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Toxic (F)
警示词
Danger
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
怎么回事？
WGK 3
闪点 (F)
Not applicable
闪点 (°C)
Not applicable