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5.05227

(-)-Cytisine

Name: (-)-Cytisine
Brand: MM

别名:

(-)-Cytisine, nAChR Agonist, (-)-Cytisine, Nicotinic Acetylcholine Receptor Agonist, (-)-Cytisine, Baptitoxine, Sophorine

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关于此项目

经验公式（希尔记法）:

C₁₁H₁₄N₂O

化学文摘社编号:

485-35-8

分子量:

190.24

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD00136048

Assay:

≥99% (HPLC)

Form:

solid

Quality level:

100

Storage condition:

OK to freeze, protect from light

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属性

assay

≥99% (HPLC)

Quality Level

100

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, protect from light

color

pale yellow

solubility

water: 100 mM

storage temp.

2-8°C

SMILES string

N21C[C@@H]3CNC[C@H](C3)C2=CC=CC1=O

InChI

1S/C11H14N2O/c14-11-3-1-2-10-9-4-8(5-12-6-9)7-13(10)11/h1-3,8-9,12H,4-7H2/t8-,9-/m0/s1

InChI key

ANJTVLIZGCUXLD-IUCAKERBSA-N

说明

General description

A potent agonist selective for neuronal nAChRs (K_i = 2, 5890, 480, 329, and 492 nM at α4β2, α7, α3β4, α6/α4β4, α1β1γδ, respectively). Clinically used as a smoking cessation medicine and often used in addiction studies.

Biochem/physiol Actions

Primary Target
nAChR

Reversible: yes

Target K_i: 2, 5890, 480, 329, and 492 nM at &alpha

Preparation Note

Following reconstitution, aliquot and freeze (-20°C. Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Chen, Y., et al., 2012. Br J Pharmacol.165, 1006.
West, R., 2011, N. Engl. J. Med.365, 1193.

Happe, K., et al., 1994. Neurosci.62, 929.

Reavill, C. et al., 1990. Neuropharmacol.29, 619.

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Toxic (F)

pictograms

GHS06

signalword

Danger

hcodes

H301 + H311 + H331

pcodes

P261 - P264 - P280 - P301 + P310 - P302 + P352 + P312 - P304 + P340 + P311

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c