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Merck
CN

5.31889

STING 激动剂,2′3′-cGAMP

≥98% (HPLC), solid, STING agonist, Calbiochem®

别名:

STING 激动剂,2′3′-cGAMP

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关于此项目

化学文摘社编号:
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
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产品名称

STING 激动剂,2′3′-cGAMP,

SMILES string

[P]1(=O)(O[C@@H]2[C@H](O[C@H]([C@@H]2O)[n]6c7ncnc(c7nc6)N)CO[P](=O)(O[C@H]3[C@@H](O[C@@H]([C@H]3O)CO1)[n]4c5[nH]c(n[c](c5nc4)=O)N)O)O

InChI

1S/C20H24N10O13P2/c21-14-8-15(24-3-23-14)29(4-25-8)18-11(32)12-7(41-18)2-39-45(36,37)43-13-10(31)6(1-38-44(34,35)42-12)40-19(13)30-5-26-9-16(30)27-20(22)28-17(9)33/h3-7,10-13,18-19,31-32H,1-2H2,(H,34,35)(H,36,37)(H2,21,23,24)(H3,22,27,28,33)/t6-,7-,10-,11-,12-,13-,18-,19-/m1/s1

InChI key

XRILCFTWUCUKJR-INFSMZHSSA-N

assay

≥98% (HPLC)

form

solid

potency

4 nM Ki

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)
protect from light

color

white

solubility

H2O: soluble

storage temp.

−20°C

Quality Level

Biochem/physiol Actions

主要靶标
STING
细胞可渗透性:具有

Disclaimer

毒性:标准处理(A)

General description

一种基于环二核苷酸(环GMP-AMP)的化合物,以高亲和力(Kd=4 nM)与连接物内质网蛋白(称为STING)的C末端结构域结合,并诱导哺乳动物细胞中干扰素-b(IFN-b)的合成(EC50=20 nM)。 显示增加与非小细胞肺癌相关的M2极化巨噬细胞中的IFN-b产生并增强M1标志物iNOS和IL-12p40的表达,同时降低M2标志物Arg-1和Fizz1的表达。对STING的亲和力比c-DiGMP,3′,2′-cGAMP和3′,3′-cGAMP高约300倍,比2′,2′-cGAMP高约75倍。

Other Notes

Wu, X., et al. 2014.Nuc.Aci.Res.42, 8243.
Zhang, X., et al. 2013.Mol.Cell.51, 226.
Wu, J., et al. 2013.Science.339, 26.

Preparation Note

复溶后,等分并冷冻保存(-20°C)。贮备液在-20°C下可稳定保存至多3个月。

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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