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Merck
CN

565950

Sialyl Lewis x, Sodium Salt

Enzymatically prepared tetrasaccharide which acts as a minimal binding ligand for E-selectins.

别名:

Sialyl Lewis x, Sodium Salt, SLe x, Neu5Acα2,3Galβ1,4(Fucα1,3)GlcNAc, SLex, Neu5Acα2,3Galβ1,4(Fucα1,3)GlcNAc

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关于此项目

经验公式（希尔记法）:
C31H51N2NaO23
化学文摘社编号:
98603-84-0
分子量:
842.73
UNSPSC Code:
12352201
NACRES:
NA.79
MDL number:
MFCD00270073

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SMILES string

N([C@H]1[C@@H](O[C@@](C[C@@H]1O)(O[C@@H]2[C@H]([C@@H](O[C@@H]([C@@H]2O)CO)O[C@@H]([C@H](O[C@@H]3O[C@H]([C@H]([C@H]([C@@H]3O)O)O)C)[C@@H](NC(=O)C)C=O)[C@H](O)CO)O)C(=O)O)[C@H](O)[C@H](O)CO)C(=O)C

InChI

1S/C31H52N2O23/c1-9-18(43)21(46)22(47)28(51-9)53-24(12(5-34)32-10(2)38)25(15(42)7-36)54-29-23(48)27(20(45)16(8-37)52-29)56-31(30(49)50)4-13(40)17(33-11(3)39)26(55-31)19(44)14(41)6-35/h5,9,12-29,35-37,40-48H,4,6-8H2,1-3H3,(H,32,38)(H,33,39)(H,49,50)/t9-,12-,13-,14+,15+,16+,17+,18+,19+,20-,21+,22-,23+,24+,25+,26+,27-,28-,29-,31-/m0/s1

InChI key

LAQPKDLYOBZWBT-NYLDSJSYSA-N

assay

≥95% (TLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

white

solubility

water: 2 mg/mL

shipped in

wet ice

storage temp.

−20°C

Quality Level

100

相关类别

General description

Enzymatically prepared tetrasaccharide which acts as a minimal binding ligand for E-selectins. SLex reduces injury following ischemia and reperfusion and immune complex-induced acute lung injury in animal models. In both of these models, SLex is presumed to act by blocking E-selectin-mediated neutrophil recruitment to sites of inflammation.

Other Notes

Seekamp, A., et al. 1994. Am. J. Pathol.144, 592.
Mulligan, M.S., et al. 1993. J. Exp. Med.178, 623.
Ichikawa, Y., et al. 1992. J. Am. Chem. Soc. 114, 9283.
Lasky, L.A. 1992. Science 258, 964.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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