681665
Wnt激动剂
The Wnt Agonist, also referenced under CAS 853220-52-7, controls the biological activity of Wnt. This small molecule/inhibitor is primarily used for Cancer applications.
别名:
Wnt激动剂, 2-氨基-4-(3,4-(亚甲二氧基)苄氨基)-6-(3-甲氧基苯基)嘧啶，Wnt通路激活剂I
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关于此项目
经验公式（希尔记法）:
C19H18N4O3
化学文摘社编号:
分子量:
350.37
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77
Assay:
≥95% (HPLC)
Form:
solid (sticky)
Quality level:
Storage condition:
OK to freeze
protect from light
protect from light
产品名称
Wnt激动剂, The Wnt Agonist, also referenced under CAS 853220-52-7, controls the biological activity of Wnt. This small molecule/inhibitor is primarily used for Cancer applications.
SMILES string
N(Cc3cc4c(cc3)OCO4)c1nc(nc(c1)c2cc(ccc2)OC)N
InChI
1S/C19H18N4O3/c1-24-14-4-2-3-13(8-14)15-9-18(23-19(20)22-15)21-10-12-5-6-16-17(7-12)26-11-25-16/h2-9H,10-11H2,1H3,(H3,20,21,22,23)
InChI key
FABQUVYDAXWUQP-UHFFFAOYSA-N
assay
≥95% (HPLC)
form
solid (sticky)
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
yellowish
solubility
DMSO: 10 mg/mL
ethanol: 5 mg/mL
shipped in
ambient
storage temp.
2-8°C
Quality Level
相关类别
Biochem/physiol Actions
EC50=700 nM诱导HEK-293T细胞的β-连环蛋白和TCF（T细胞命运）依赖性转录活性。
主靶
Wnt信号的选择性激活剂
Wnt信号的选择性激活剂
产物不与ATP竞争。
可逆：否
细胞可渗透性：是
Disclaimer
毒性：标准处理（A）
General description
一种Wnt信号的细胞渗透性、有效和选择性激活剂，不抑制GSK-3β（IC50 >60 µM）的活性。显示出模拟Wnt的作用并诱导β-连环蛋白和TCF（T细胞命运）依赖性转录活性（HEK-293T细胞中的EC50 = 700 nM）。据报道，在非洲爪蟾胚胎发育过程中导致大量头部缺陷。
Other Notes
Liu, J., et al. 2005.Angew.Chem. Int. Ed.44, 1987.
Packaging
用惰性气体包装
Preparation Note
复溶后，等分并冷冻保存（-20°C）。贮备溶液在-20°C下可稳定保存至多6个月。
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Chiharu Kimura-Yoshida et al.
Communications biology, 5(1), 378-378 (2022-04-21)
Previously, we have shown that the translocation of Grainyhead-like 3 (GRHL3) transcription factor from the nucleus to the cytoplasm triggers the switch from canonical Wnt signaling for epidermal differentiation to non-canonical Wnt signaling for epithelial morphogenesis. However, the molecular mechanism
Camille Cohen et al.
Nature communications, 15(1), 743-743 (2024-01-26)
Chronic kidney disease (CKD) is a public health problem driven by myofibroblast accumulation, leading to interstitial fibrosis. Heterogeneity is a recently recognized characteristic in kidney fibroblasts in CKD, but the role of different populations is still unclear. Here, we characterize
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