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Merck
CN

8.17073

反丁烯二酸

EMPROVE® ESSENTIAL, NF, JPE

别名:

Fumaric acid, trans-1,2-Ethylentricarboxylic acid

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关于此项目

经验公式（希尔记法）:
C4H4O4
化学文摘社编号:
110-17-8
分子量:
116.07
UNSPSC Code:
12352106
EC Index Number:
203-743-0
MDL number:
MFCD00002700

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SMILES string

[O-]C(=O)\C=C\C(=O)[O-].[H+].[H+]

InChI

1S/C4H4O4/c5-3(6)1-2-4(7)8/h1-2H,(H,5,6)(H,7,8)/b2-1+

InChI key

VZCYOOQTPOCHFL-OWOJBTEDSA-N

agency

JPE, NF

vapor pressure

<0.001 hPa ( 20 °C)

product line

EMPROVE® ESSENTIAL

form

solid

autoignition temp.

375 °C

potency

9300 mg/kg LD50, oral (Rat), 20000 mg/kg LD50, skin (Rabbit)

technique(s)

API processing | cocrystal formation: suitable, API processing | salt formation: suitable

pH

2.1 (20 °C, 4.9 g/L in H2O)

bp

290 °C/1013 hPa (sublimed)

mp

287 °C

transition temp

flash point 273 °C

solubility

4.9 g/L

density

1.64 g/cm3 at 20 °C

application(s)

liquid formulation
pharmaceutical
solid formulation

storage temp.

15-25°C

Quality Level

500

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General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our EMPROVE® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Fumaric acid is a commonly used ingredient in both food and pharmaceutical applications. In pharmaceutical applications, fumaric acid has been used primarily as a pH modifier.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H319

Hazard Classifications

Eye Irrit. 2

存储类别

11 - Combustible Solids

wgk

WGK 1

flash_point_f

523.4 °F

flash_point_c

273 °C

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商品

Improving API Solubility using API Processing

Instead of addressing API solubility during formulation, tackle it early during development. Read about the various methods for API processing.

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