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Merck
CN

8.51085

Sigma-Aldrich

COMU

greener alternative

≥99.0% (HPLC), for peptide synthesis, Novabiochem®

别名:

COMU, 1-[(1-(Cyano-2-ethoxy-2-oxoethylideneaminooxy)-dimethylamino-morpholino)] uronium hexafluorophosphate

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About This Item

经验公式（希尔记法）:
C12H19F6N4O4P
CAS Number:
1075198-30-9
分子量:
428.27
MDL编号:
MFCD11975052
UNSPSC代码:
12352107
NACRES:
NA.22

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Product Name

COMU, 1-[(1-(Cyano-2-ethoxy-2-oxoethylideneaminooxy) dimethylaminomorpholino)] uronium hexafluorophosphate Novabiochem®

质量水平

300

产品线

Novabiochem®

方案

≥99.0% (HPLC)

表单

powder

反应适用性

reaction type: Coupling Reactions

制造商/商品名称

Novabiochem®

环保替代产品特性

Less Hazardous Chemical Syntheses
Inherently Safer Chemistry for Accident Prevention
Learn more about the Principles of Green Chemistry.

sustainability

Greener Alternative Product

mp

>140 °C

应用

peptide synthesis

环保替代产品分类

Aligned

储存温度

15-25°C

SMILES字符串

F[P-](F)(F)(F)(F)F.N1(CCOCC1)C(=[O+]\N=C(/C(=O)OCC)\C#N)N(C)C

InChI

1S/C12H19N4O4.F6P/c1-4-19-11(17)10(9-13)14-20-12(15(2)3)16-5-7-18-8-6-16;1-7(2,3,4,5)6/h4-8H2,1-3H3;/q+1;-1/b14-10-;

InChI key

GPDHNZNLPKYHCN-DZOOLQPHSA-N

相关类别

一般描述

COMU is a novel reagent which mediates coupling reactions with efficiencies comparable to HATU [1,2].It has higher solubility than HATU and HBTU. Furthermore, it is not explosive under normal operating conditions and is less likely to exhibit allergenicity compared to other coupling reagents. Recently, the application of COMU in the preparation of esters has been demonstrated [3].

Associated Protocols and Technical Articles
Guide to Selection of Coupling Reagents

Literature references

[1] A. El-Faham, et al. (2009) Chem. Eur. J., 15, 9404.
[2] A. El-Faham & F. Albericio (2010) J. Pept. Sci., 16, 6.
[3] Jean-d′Amour, et al. (2011) Org. Lett., 13, 2988.
We are committed to bringing you Greener Alternative Products, which adhere to one or more of the 12 Principles of Green Chemistry. This product is a Safer, non-explosive and more effective replacement for Benzotriazole-Based peptide coupling reagents and thus aligns with "Less Hazardous Chemical Synthesis" and "Inherently Safer Chemistry for Accident Prevention". Click here for more information.

应用

  • Re-evaluating the stability of COMU in different solvents: This study highlights the robust stability and effectiveness of COMU, promoting its use in various peptide synthesis scenarios, enhancing both scalability and environmental friendliness (Kumar et al., 2017).

分析说明

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Assay (HPLC, area%): ≥ 99.0 % (a/a)
Solubility (10% in acetonitrile): clear

法律信息

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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