8.51095
PyOxim
≥99.0% (HPLC), for peptide synthesis, Novabiochem®
别名:
PyOxim, 1-Cyano-2-ethoxy-2-oxoethylideneaminooxy-tris-pyrrolidino-phosphonium hexafluorophosphate
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关于此项目
经验公式（希尔记法）:
C17H29F6N5O3P2
化学文摘社编号:
分子量:
527.38
UNSPSC Code:
12352126
NACRES:
NA.22
MDL number:
产品名称
PyOxim, Novabiochem®
Quality Segment
product line
Novabiochem®
assay
≥99.0% (HPLC)
form
powder
reaction suitability
reaction type: Coupling Reactions
manufacturer/tradename
Novabiochem®
application(s)
peptide synthesis
storage temp.
-10 to -25°C
SMILES string
F[P-](F)(F)(F)(F)F.[P](=[N+]3CCCC3)(N2CCCC2)(N1CCCC1)O\N=C(\C(=O)OCC)/C#N
InChI
1S/C17H29N5O3P.F6P/c1-2-24-17(23)16(15-18)19-25-26(20-9-3-4-10-20,21-11-5-6-12-21)22-13-7-8-14-22;1-7(2,3,4,5)6/h2-14H2,1H3;/q+1;-1/b19-16+;
InChI key
RDWDVLFMPFUBDV-PXMDEAMVSA-N
General description
PyOxim [1] is a novel reagent which mediates coupling reactions with efficiencies superior to HATU and PyBOP and comparable to COMU. It is has excellent solubility in DMF and is stable in solution under an inert atmosphere for two days. Unlike HATU and HBTU, it cannot cause chain terminating side reactions and is, therefore, ideal for the synthesis of cyclic peptides. Furthermore, it is not explosive under normal operating conditions and is less likely to exhibit allergenicity compared to other coupling reagents.
Associated Protocols and Technical Articles
Guide to Selection of Coupling Reagents
Literature references
[1] R. Subiros-Funosas, et al. (2010) Org. Biomol. Chem., 8, 3665.
Associated Protocols and Technical Articles
Guide to Selection of Coupling Reagents
Literature references
[1] R. Subiros-Funosas, et al. (2010) Org. Biomol. Chem., 8, 3665.
Features and Benefits
- Mediates coupling with superior efficiency to PyBOP, TBTU, and HCTU
- Mediates coupling with low racemization or epimerization
- Ideal for fragment condensation and synthesis of cyclic peptides as the reagent cannot cause guanidinylation
- Excellent solubility in DMF and NMP
Analysis Note
Colour (visual): white to off white
Appearance of substance (visual): powder
Identity (IR): passes test
Assay (HPLC, area%): ≥ 99.0 %
Solubility (1 mmole in 2 ml DMF): clearly soluble
Appearance of substance (visual): powder
Identity (IR): passes test
Assay (HPLC, area%): ≥ 99.0 %
Solubility (1 mmole in 2 ml DMF): clearly soluble
Legal Information
Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable