8.51095
PyOxim
≥99.0% (HPLC), for peptide synthesis, Novabiochem®
别名:
PyOxim, 1-Cyano-2-ethoxy-2-oxoethylideneaminooxy-tris-pyrrolidino-phosphonium hexafluorophosphate
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关于此项目
经验公式（希尔记法）:
C17H29F6N5O3P2
化学文摘社编号:
分子量:
527.38
UNSPSC Code:
12352126
NACRES:
NA.22
MDL number:
产品名称
PyOxim, Novabiochem®
Quality Level
product line
Novabiochem®
assay
≥99.0% (HPLC)
form
powder
reaction suitability
reaction type: Coupling Reactions
manufacturer/tradename
Novabiochem®
application(s)
peptide synthesis
storage temp.
-10 to -25°C
SMILES string
F[P-](F)(F)(F)(F)F.[P](=[N+]3CCCC3)(N2CCCC2)(N1CCCC1)O\N=C(\C(=O)OCC)/C#N
InChI
1S/C17H29N5O3P.F6P/c1-2-24-17(23)16(15-18)19-25-26(20-9-3-4-10-20,21-11-5-6-12-21)22-13-7-8-14-22;1-7(2,3,4,5)6/h2-14H2,1H3;/q+1;-1/b19-16+;
InChI key
RDWDVLFMPFUBDV-PXMDEAMVSA-N
General description
PyOxim [1] is a novel reagent which mediates coupling reactions with efficiencies superior to HATU and PyBOP and comparable to COMU. It is has excellent solubility in DMF and is stable in solution under an inert atmosphere for two days. Unlike HATU and HBTU, it cannot cause chain terminating side reactions and is, therefore, ideal for the synthesis of cyclic peptides. Furthermore, it is not explosive under normal operating conditions and is less likely to exhibit allergenicity compared to other coupling reagents.
Associated Protocols and Technical Articles
Guide to Selection of Coupling Reagents
Literature references
[1] R. Subiros-Funosas, et al. (2010) Org. Biomol. Chem., 8, 3665.
Associated Protocols and Technical Articles
Guide to Selection of Coupling Reagents
Literature references
[1] R. Subiros-Funosas, et al. (2010) Org. Biomol. Chem., 8, 3665.
Features and Benefits
- Mediates coupling with superior efficiency to PyBOP, TBTU, and HCTU
- Mediates coupling with low racemization or epimerization
- Ideal for fragment condensation and synthesis of cyclic peptides as the reagent cannot cause guanidinylation
- Excellent solubility in DMF and NMP
Analysis Note
Colour (visual): white to off white
Appearance of substance (visual): powder
Identity (IR): passes test
Assay (HPLC, area%): ≥ 99.0 %
Solubility (1 mmole in 2 ml DMF): clearly soluble
Appearance of substance (visual): powder
Identity (IR): passes test
Assay (HPLC, area%): ≥ 99.0 %
Solubility (1 mmole in 2 ml DMF): clearly soluble
Legal Information
Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
商品
Novabiochem® coupling reagents for in situ activation are fast-reacting and compatible with various amino acids.
Novabiochem®可提供大量的偶联剂用于原位活化。原位活化试剂易于使用 - 即使是利用空间位阻氨基酸，并且它们的使用通常没有副反应。
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 8510950025 | 04027269226442 |
| 8510950100 | 04027269226480 |