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8.52006

Fmoc-Cys(Acm)-OH

Name: Fmoc-Cys(Acm)-OH
Brand: MM

≥99.0% (HPLC), for peptide synthesis, Novabiochem^®

别名:

Fmoc-Cys(Acm)-OH, N-α-Fmoc-S-acetamidomethyl-L-cysteine

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关于此项目

经验公式（希尔记法）:

C₂₁H₂₂N₂O₅S

化学文摘社编号:

86060-81-3

分子量:

414.47

UNSPSC Code:

12352209

NACRES:

NA.22

MDL number:

MFCD00038769

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属性

产品名称

Fmoc-Cys(Acm)-OH, Novabiochem^®

Quality Level

200

product line

Novabiochem^®

assay

≥96.0% (acidimetric), ≥98% (TLC), ≥99.0% (HPLC)

form

powder

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

manufacturer/tradename

Novabiochem^®

mp

147-150 °C

application(s)

peptide synthesis

functional group

thiol

storage temp.

2-30°C

SMILES string

S(CNC(=O)C)C[C@H](NC(=O)OCC1c2c(cccc2)c3c1cccc3)C(=O)O

InChI

1S/C21H22N2O5S/c1-13(24)22-12-29-11-19(20(25)26)23-21(27)28-10-18-16-8-4-2-6-14(16)15-7-3-5-9-17(15)18/h2-9,18-19H,10-12H2,1H3,(H,22,24)(H,23,27)(H,25,26)/t19-/m0/s1

InChI key

CSMYOORPUGPKAP-IBGZPJMESA-N

说明

General description

The side-chain Acm group is stable to TFA but can be removed with Hg(II) ^[1] or Ag(I) ^[2] to give cysteinyl peptides, or oxidatively with Tl(III) ^[3] or I₂ ^[4] to generate cystinyl peptides.

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS
Fmoc SPPS of Cysteine-Containing Peptides

Literature references

^[1] D. F. Veber, et al. (1972) J. Am. Chem. Soc., 94, 5456.
^[2] M. Yoshida, et al. (1990) Chem. Pharm. Bull., 38, 273.
^[3] N. Fujii, et al. (1987) Chem. Pharm. Bull., 36, 2339.
^[4] B. Kamber, et al. (1980) Helv. Chim. Acta, 63, 899.

Analysis Note

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Enantiomeric purity: ≥ 99.5 % (a/a)
Purity (TLC(011B)): ≥ 98 %
Purity (TLC(0811)): ≥ 98 %
Assay (HPLC, area%): ≥ 99.0 % (a/a)
Solubility (25 mmole in 50 ml DMF): clearly soluble
UV/VIS (E(450 bis 600 nm)): ≤ 50 mAU
Assay (acidimetric): ≥ 96.0 %
Water (K. F.): ≤ 5.00 %

To see the solvent systems used for TLC of Novabiochem^® products please click here.

Other Notes

Replaces: 04-12-1014

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

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pictograms

GHS07

signalword

Warning

hcodes

H315 - H319 - H335

pcodes

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c