8.52007
Fmoc-Cys(tBu)-OH
Novabiochem®
别名:
Fmoc-Cys(tBu)-OH, N-α-Fmoc-S-t.-butyl-L-cysteine
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关于此项目
经验公式（希尔记法）:
C22H25NO4S
化学文摘社编号:
分子量:
399.50
UNSPSC Code:
12352209
NACRES:
NA.22
MDL number:
产品名称
Fmoc-Cys(tBu)-OH, Novabiochem®
assay
≥98.0% (HPLC)
≥97.0% (acidimetric)
≥98% (TLC)
form
powder
SMILES string
S(C(C)(C)C)CC(NC(=O)OCC1c2c(cccc2)c3c1cccc3)C(=O)O
InChI
1S/C22H25NO4S/c1-22(2,3)28-13-19(20(24)25)23-21(26)27-12-18-16-10-6-4-8-14(16)15-9-5-7-11-17(15)18/h4-11,18-19H,12-13H2,1-3H3,(H,23,26)(H,24,25)
InChI key
IXAYZHCPEYTWHW-UHFFFAOYSA-N
product line
Novabiochem®
reaction suitability
reaction type: Fmoc solid-phase peptide synthesis
manufacturer/tradename
Novabiochem®
mp
133-136 °C
application(s)
peptide synthesis
functional group
thiol
storage temp.
2-30°C
Quality Level
Analysis Note
Colour (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Enantiomeric purity: ≥ 99.5 % (a/a)
Purity (TLC(011A)): ≥ 98 %
Purity (TLC(0811)): ≥ 98 %
Assay (HPLC, area%): ≥ 98.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble
Assay (acidimetric): ≥ 97.0 %
Water (K. F.): ≤ 1.00 %
To see the solvent systems used for TLC of Novabiochem® products please click here.
Appearance of substance (visual): powder
Identity (IR): passes test
Enantiomeric purity: ≥ 99.5 % (a/a)
Purity (TLC(011A)): ≥ 98 %
Purity (TLC(0811)): ≥ 98 %
Assay (HPLC, area%): ≥ 98.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble
Assay (acidimetric): ≥ 97.0 %
Water (K. F.): ≤ 1.00 %
To see the solvent systems used for TLC of Novabiochem® products please click here.
General description
The side-chain tBu group is stable to TFA and iodine oxidation. Treatment with MeSiCl3/PhSOPh removes t-Bu and cyclizes in one step without scrambling existing disulphide bonds. Removed with Hg(II) to give cysteinyl peptides.
Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS
Fmoc SPPS of Cysteine-Containing Peptides
Literature references
[1] S. N. McCurdy (1989) Pept. Res., 2, 147.
Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS
Fmoc SPPS of Cysteine-Containing Peptides
Literature references
[1] S. N. McCurdy (1989) Pept. Res., 2, 147.
Other Notes
Replaces: 04-12-1016
Legal Information
Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
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实验方案
Overcome challenges in synthesis and disulfide bond formation with protocols for Fmoc solid-phase peptide synthesis of peptides with cysteine and methionine.
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