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Merck
CN

8.52066-M

Sigma-Aldrich

Fmoc-Thr(Trt)-OH

Novabiochem®

别名:

Fmoc-Thr(Trt)-OH, N-α-Fmoc-O-trityl-L-threonine

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关于此项目

经验公式（希尔记法）:
C38H33NO5
CAS Number:
133180-01-5
分子量:
583.67
MDL编号:
MFCD00237034
UNSPSC代码:
12352209
NACRES:
NA.22

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质量水平

200

方案

≥78.0% (acidimetric)
≥98% (TLC)
≥98.0% (HPLC)

表单

powder

反应适用性

reaction type: Fmoc solid-phase peptide synthesis

制造商/商品名称

Novabiochem®

mp

70-85 °C

应用

peptide synthesis

官能团

hydroxyl

储存温度

15-25°C

SMILES字符串

N([C@@H]([C@H](OC(c6ccccc6)(c5ccccc5)c4ccccc4)C)C(=O)O)C(=O)OCC1c2c(cccc2)c3c1cccc3

InChI

1S/C38H33NO5/c1-26(44-38(27-15-5-2-6-16-27,28-17-7-3-8-18-28)29-19-9-4-10-20-29)35(36(40)41)39-37(42)43-25-34-32-23-13-11-21-30(32)31-22-12-14-24-33(31)34/h2-24,26,34-35H,25H2,1H3,(H,39,42)(H,40,41)/t26-,35+/m1/s1

InChI key

JARBLLDDSTVWSM-IJAHGLKVSA-N

相关类别

一般描述

The side-chain Trt group can be selectively removed with 1% TFA in DCM containing 5% TIS, enabling the side-chain hydroxyl group to be selectively modified whilst the derivative is attached to the solid support. This is an excellent derivative for the synthesis of phosphothreonine containing peptides and peptides modified at the threonine side-chain [1]. The use of trityl protected amino acids was shown to result in purer products than when standard t-Bu protected amino acids were utilized [2].

The product number for this product was previously 04-12-1141.

To obtain a certificate of analysis (CoA) of a lot that begins with the letter “A”, please select the option in the right hand menu “Request a COA for Lot#s starting with A”.

分析说明

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Enantiomeric purity: ≥ 99.0 % (a/a)
Purity (TLC(011A)): ≥ 98 %
Purity (TLC(0811)): ≥ 98 %
Assay (HPLC, area%): ≥ 98.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble
Assay (acidimetric): ≥ 78.0 %
Water (K. F.): ≤ 1.5 %

To see the solvent systems used for TLC of Novabiochem® products please click here.

其他说明

Replaces: 04-12-1141

法律信息

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

储存分类代码

11 - Combustible Solids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

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Selecting Orthogonal Building Blocks

Novabiochem® offers orthogonally protected amino acids for peptide synthesis, including cyclic and branched peptides.

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