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Merck
CN

8.52112

Fmoc-Lys(Me3Cl)-OH

Novabiochem®

别名:

Fmoc-Lys(Me₃Cl)-OH, N-α-Fmoc-N-ε-trimethyl-N-L-lysine · chloride

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关于此项目

经验公式(希尔记法):
C24H31ClN2O4
化学文摘社编号:
分子量:
446.97
MDL number:
UNSPSC Code:
12352209
NACRES:
NA.22
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Quality Level

product line

Novabiochem®

assay

≥95% (TLC), ≥95.0% (HPLC)

form

powder

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

manufacturer/tradename

Novabiochem®

application(s)

peptide synthesis

functional group

amine

storage temp.

2-8°C

SMILES string

Cl.[N+](CCCC[C@H](N=C([O-])OCC1c2c(cccc2)c3c1cccc3)C(=O)O)(C)(C)C

InChI

1S/C24H30N2O4.ClH/c1-26(2,3)15-9-8-14-22(23(27)28)25-24(29)30-16-21-19-12-6-4-10-17(19)18-11-5-7-13-20(18)21;/h4-7,10-13,21-22H,8-9,14-16H2,1-3H3,(H-,25,27,28,29);1H/t22-;/m0./s1

InChI key

XUJRNPVABVHOAJ-FTBISJDPSA-N

General description

A novel derivative for the introduction of trimethyl-lysine during Fmoc SPPS. Ref [1] contains methods and protocols for the synthesis of arrays of histone-related peptides containing methylated arginine and lysine-residues.


Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS
Overcoming Aggregation in Fmoc SPPS

Literature references

[1] S. Rothbart, et al. (2012) Methods Enzymol., 512, 107.

Analysis Note

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Purity (TLC(CMA1)): ≥ 95 %
Assay (HPLC, area%): ≥ 95.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble
LC/MS: passes test

To see the solvent systems used for TLC of Novabiochem® products please click here.

Other Notes

Replaces: 04-12-1270

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany


存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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实验方案

We provide an overview of our available reagents, together with recommendations and details of their use for synthesis of peptides containing post-translationally modified amino acids.

商品

Unnatural amino acids, the non-proteinogenic amino acids that either occur naturally or are chemically synthesized, are becoming more and more important as tools for modern drug discovery research.





全球贸易项目编号

货号GTIN
852112000504027269137885
852112000104027269089832
852112850004027269089849