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Merck
CN

8.52115

Fmoc-Asp(OtBu)-(Dmb)Gly-OH

≥98% (TLC), for peptide synthesis, Novabiochem®

别名:

Fmoc-Asp(OtBu)-(Dmb)Gly-OH, N-α-Fmoc-β-O-t.-butyl-L-aspartyl-N-α-(2,4-dimethoxybenzyl)-glycine

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关于此项目

经验公式（希尔记法）:
C34H38N2O9
化学文摘社编号:
900152-72-9
分子量:
618.67
MDL number:
MFCD10001337
UNSPSC Code:
12352209
NACRES:
NA.22

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产品名称

Fmoc-Asp(OtBu)-(Dmb)Gly-OH, Novabiochem®

SMILES string

N([C@@H](CC(=O)O)C(=O)N(Cc4c(cc(cc4)OC)OC)CC(=O)OC(C)(C)C)C(=O)OCC1c2c(cccc2)c3c1cccc3

InChI

1S/C34H38N2O9/c1-34(2,3)45-31(39)19-36(18-21-14-15-22(42-4)16-29(21)43-5)32(40)28(17-30(37)38)35-33(41)44-20-27-25-12-8-6-10-23(25)24-11-7-9-13-26(24)27/h6-16,27-28H,17-20H2,1-5H3,(H,35,41)(H,37,38)/t28-/m0/s1

InChI key

JWWOZAAYQXZHGO-NDEPHWFRSA-N

product line

Novabiochem®

assay

≥90.0% (acidimetric), ≥97.0% (HPLC), ≥98% (TLC)

form

powder

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

manufacturer/tradename

Novabiochem®

application(s)

peptide synthesis

functional group

Fmoc

storage temp.

2-8°C

Quality Level

200

相关类别

General description

Fmoc-Aaa-(Dmb)Gly-OH dipeptides offer the same benefits as pseudoproline dipeptides in Fmoc SPPS but for peptide sequences containing Gly. They are extremely easy to use. Standard coupling methods like PyBOP® /DIPEA or DIPCDI/HOBt can be used for their introduction. Removal of the Dmb group and regeneration of the glycine residue occurs during the course of standard TFA-mediated cleavage reaction. This derivative also completely inhibits aspartimide formation.

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS
Overcoming Aggregation in Fmoc SPPS

Analysis Note

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Optical rotation α 25/D (c=1 in methanol): -24.0 - -20.0 °
Purity (TLC(157A)): ≥ 98 %
Assay (HPLC, area%): ≥ 97.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble
Assay (acidimetric): ≥ 90.0 %
Water (K. F.): ≤ 1.50 %

To see the solvent systems used for TLC of Novabiochem® products please click here.

Other Notes

Replaces: 04-12-1282

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany
PyBOP is a registered trademark of Merck KGaA, Darmstadt, Germany

存储类别

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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实验方案

Overcoming Aggregation in Solid-phase Peptide Synthesis

The ease of assembly of a given peptide sequence is hard to predict, which makes peptide synthesis challenging. Review methods and reagents for avoiding aggregation in solid-phase peptide synthesis.

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