8.52126
Fmoc-Cys(Trt)-OPfp
Novabiochem®
别名:
Fmoc-Cys(Trt)-OPfp, N-α-Fmoc-S-trityl-L-cysteine pentafluorophenyl ester
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关于此项目
经验公式（希尔记法）:
C43H30F5NO4S
化学文摘社编号:
分子量:
751.76
UNSPSC Code:
12352209
NACRES:
NA.22
MDL number:
产品名称
Fmoc-Cys(Trt)-OPfp, Novabiochem®
SMILES string
Fc1c(c(c(c(c1F)F)OC(=O)[C@@H](NC(=O)OCC5c6c(cccc6)c7c5cccc7)CSC(c4ccccc4)(c3ccccc3)c2ccccc2)F)F
InChI
1S/C43H30F5NO4S/c44-35-36(45)38(47)40(39(48)37(35)46)53-41(50)34(49-42(51)52-24-33-31-22-12-10-20-29(31)30-21-11-13-23-32(30)33)25-54-43(26-14-4-1-5-15-26,27-16-6-2-7-17-27)28-18-8-3-9-19-28/h1-23,33-34H,24-25H2,(H,49,51)/t34-/m0/s1
InChI key
FDAUCYDVXIPBDR-UMSFTDKQSA-N
product line
Novabiochem®
assay
≥97.0% (HPLC)
form
powder
reaction suitability
reaction type: Fmoc solid-phase peptide synthesis
manufacturer/tradename
Novabiochem®
application(s)
peptide synthesis
functional group
thiol
storage temp.
15-25°C
Quality Level
Analysis Note
Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Optical rotation α 25/D (c=1 in chloroform): +14.0 - +17.0 °
Purity (TLC (0004)): <3% DCU
Assay (HPLC, area%): ≥ 97.0% (a/a)
Solubility (0,5 mmole in 3 ml DMF): clearly soluble
To see the solvent systems used for TLC of Novabiochem® products please click here.
Appearance of substance (visual): powder
Identity (IR): passes test
Optical rotation α 25/D (c=1 in chloroform): +14.0 - +17.0 °
Purity (TLC (0004)): <3% DCU
Assay (HPLC, area%): ≥ 97.0% (a/a)
Solubility (0,5 mmole in 3 ml DMF): clearly soluble
To see the solvent systems used for TLC of Novabiochem® products please click here.
General description
Pre-formed pentafluorophenyl ester for coupling of cysteine residues for Fmoc SPPS without enantiomerization [1,2]. Enables use of bromophenol blue monitoring of amide bond formation.
Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS
Fmoc SPPS of Cysteine-Containing Peptides
Literature references
[1] T. Kaiser, et al. (1996) Tetrahedron Lett., 37, 1187.
[2] Y. X. Han, et al. (1997) J. Org. Chem., 62, 4307
Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS
Fmoc SPPS of Cysteine-Containing Peptides
Literature references
[1] T. Kaiser, et al. (1996) Tetrahedron Lett., 37, 1187.
[2] Y. X. Han, et al. (1997) J. Org. Chem., 62, 4307
Other Notes
Replaces: 04-12-1504
Legal Information
Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Warning
hcodes
Hazard Classifications
Skin Irrit. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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