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Merck
CN

8.52177

Sigma-Aldrich

Fmoc-Glu(OtBu)-Ser(psiMe,Mepro)-OH

Novabiochem®

别名:

Fmoc-Glu(OtBu)-Ser(psiMe,Mepro)-OH

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关于此项目

经验公式（希尔记法）:
C30H36N2O8
化学文摘社编号:
909115-33-9
分子量:
552.62
MDL编号:
MFCD18427719
UNSPSC代码:
12352209
NACRES:
NA.22

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质量水平

200

产品线

Novabiochem®

方案

≥97% (TLC)
≥97.0% (HPLC)

表单

powder

反应适用性

reaction type: Fmoc solid-phase peptide synthesis

制造商/商品名称

Novabiochem®

应用

peptide synthesis

官能团

hydroxyl

储存温度

2-8°C

SMILES字符串

N4([C@@H](COC4(C)C)C(=O)O)C(=O)[C@@H](NC(=O)OCC1c2c(cccc2)c3c1cccc3)CCC(=O)OC(C)(C)C

InChI

1S/C30H36N2O8/c1-29(2,3)40-25(33)15-14-23(26(34)32-24(27(35)36)17-39-30(32,4)5)31-28(37)38-16-22-20-12-8-6-10-18(20)19-11-7-9-13-21(19)22/h6-13,22-24H,14-17H2,1-5H3,(H,31,37)(H,35,36)/t23-,24-/m0/s1

InChI key

DSGXIRQTDFOKPQ-ZEQRLZLVSA-N

相关类别

一般描述

This pseudoproline dipeptide is undoubtedly the most effective and simplest to use tool for overcoming aggregation and enhancing peptide quality in Fmoc SPPS for peptide containing the Glu-Ser dipeptide motif. It consists of a dipeptide in which the serine residue has been reversibly protected as a structure-breaking proline-like TFA-labile oxazolidine. The reason the pseudoproline residue is introduced as a dipeptide is because it avoids the need to acylate the hindered oxazolidine nitrogen. This has the added advantage of extending the peptide chain by two residues in one step. The serine residue is regenerated during the normal TFA-mediated cleavage reaction.

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS
Overcoming Aggregation in Fmoc SPPS

分析说明

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Purity (TLC(157A)): ≥ 97 %
Purity (TLC(CMA2)): ≥ 97 %
Assay (HPLC, area%): ≥ 97.0 % (a/a)
Ethyl acetate (HS-GC): ≤ 2.0 %
Acetate (IC): ≤ 0.1 %

To see the solvent systems used for TLC of Novabiochem® products please click here.

其他说明

Replaces: 05-20-1002

法律信息

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

储存分类代码

11 - Combustible Solids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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实验方案

Overcoming Aggregation in Solid-phase Peptide Synthesis

The ease of assembly of a given peptide sequence is hard to predict, which makes peptide synthesis challenging. Review methods and reagents for avoiding aggregation in solid-phase peptide synthesis.

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