8.53022
Boc-Trp(For)-OH
Novabiochem®
别名:
Boc-Trp(For)-OH, N-α-t.-Boc-N-in-formyl-L-tryptophan
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关于此项目
经验公式（希尔记法）:
C17H20N2O5
化学文摘社编号:
分子量:
332.35
UNSPSC Code:
12352209
NACRES:
NA.22
MDL number:
SMILES string
[n]1(c2c(c(c1)C[C@H](NC(=O)OC(C)(C)C)C(=O)O)cccc2)C=O
InChI
1S/C17H20N2O5/c1-17(2,3)24-16(23)18-13(15(21)22)8-11-9-19(10-20)14-7-5-4-6-12(11)14/h4-7,9-10,13H,8H2,1-3H3,(H,18,23)(H,21,22)/t13-/m0/s1
InChI key
IHXHBYFWSOYYTR-ZDUSSCGKSA-N
product line
Novabiochem®
assay
≥98% (TLC)
form
powder
reaction suitability
reaction type: Boc solid-phase peptide synthesis
manufacturer/tradename
Novabiochem®
mp
100 °C (decomposition)
application(s)
peptide synthesis
storage temp.
15-25°C
Quality Level
General description
Standard building block for introduction of tryptophan by Boc SPPS. The formyl group is stable to standard high HF cleavage but can be removed by HF containing thiophenol [1,2,3]. The formyl group can also be removed with piperidine in DMF prior to HF cleavage.
Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Boc SPPS
Literature references
[1] M. Ohno, et al. (1973) Bull. Chem. Soc. Jpn., 46, 3280.
[2] W. F. Heath, et al. (1982) J. Chem. Soc., Chem. Commun., 896.
[3] G. R. Matsueda (1982) Int. J. Peptide Protein Res., 20, 26.
Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Boc SPPS
Literature references
[1] M. Ohno, et al. (1973) Bull. Chem. Soc. Jpn., 46, 3280.
[2] W. F. Heath, et al. (1982) J. Chem. Soc., Chem. Commun., 896.
[3] G. R. Matsueda (1982) Int. J. Peptide Protein Res., 20, 26.
Analysis Note
Colour (visual): white to off white
Appearance of substance (visual): powder
Identity (IR): passes test
Enantiomeric purity: ≥ 99.0 % (a/a)
Purity (TLC(0811)): ≥ 98 %
Purity (TLC(011A)): ≥ 98 %
Solubility (1 mmole in 2 ml DMF): clearly soluble
To see the solvent systems used for TLC of Novabiochem® products please click here.
Appearance of substance (visual): powder
Identity (IR): passes test
Enantiomeric purity: ≥ 99.0 % (a/a)
Purity (TLC(0811)): ≥ 98 %
Purity (TLC(011A)): ≥ 98 %
Solubility (1 mmole in 2 ml DMF): clearly soluble
To see the solvent systems used for TLC of Novabiochem® products please click here.
Other Notes
Replaces: 04-12-0087
Legal Information
Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
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实验方案
Anhydrous HF is the preferred reagent for peptide cleavage from Boc-based resins, versatile and effective for various peptide synthesis.
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