8.53075
Boc-Gln(Trt)-OH
Novabiochem®
别名:
Boc-Gln(Trt)-OH, N-α-t.-Boc-γ-trityl-L-glutamine
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关于此项目
经验公式（希尔记法）:
C29H32N2O5
化学文摘社编号:
分子量:
488.57
UNSPSC Code:
12352209
NACRES:
NA.22
MDL number:
产品名称
Boc-Gln(Trt)-OH, Novabiochem®
form
powder
SMILES string
N([C@@H](CCC(=O)NC(c3ccccc3)(c2ccccc2)c1ccccc1)C(=O)O)C(=O)OC(C)(C)C
InChI
1S/C29H32N2O5/c1-28(2,3)36-27(35)30-24(26(33)34)19-20-25(32)31-29(21-13-7-4-8-14-21,22-15-9-5-10-16-22)23-17-11-6-12-18-23/h4-18,24H,19-20H2,1-3H3,(H,30,35)(H,31,32)(H,33,34)/t24-/m0/s1
InChI key
YEXNCDUSVVLUFM-DEOSSOPVSA-N
product line
Novabiochem®
assay
≥98% (TLC)
reaction suitability
reaction type: Boc solid-phase peptide synthesis
manufacturer/tradename
Novabiochem®
application(s)
peptide synthesis
functional group
amide
storage temp.
15-25°C
Quality Level
Analysis Note
Colour (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Optical rotation α 25/D (c=1 in methanol): -3.0 - -2.0 °
Purity (TLC(011A)): ≥ 98 %
Purity (TLC(0811)): ≥ 98 %
Solubility (1 mmole in 2 ml DMF): clear solution
To see the solvent systems used for TLC of Novabiochem® products please click here.
Appearance of substance (visual): powder
Identity (IR): passes test
Optical rotation α 25/D (c=1 in methanol): -3.0 - -2.0 °
Purity (TLC(011A)): ≥ 98 %
Purity (TLC(0811)): ≥ 98 %
Solubility (1 mmole in 2 ml DMF): clear solution
To see the solvent systems used for TLC of Novabiochem® products please click here.
General description
A trityl-protected derivative which increases the solubility of glutamine during the coupling step in SPPS [1]. Its use gives higher yields and lower by-product formation. During the following coupling cycles the temporary side-chain protection is removed.
Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Boc SPPS
Literature references
[1] P. Sieber, et al. (1991) Tetrahedron Lett., 32, 739.
Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Boc SPPS
Literature references
[1] P. Sieber, et al. (1991) Tetrahedron Lett., 32, 739.
Other Notes
Replaces: 04-12-0188
Legal Information
Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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