Quality Level
product line
Novabiochem®
form
beads
reaction suitability
reaction type: Fmoc solid-phase peptide synthesis
manufacturer/tradename
Novabiochem®
application(s)
peptide synthesis
functional group
alcohol
storage temp.
2-30°C
General description
This support consists of MBHA resin functionalized with Riniker′s hyperacid-labile 4-hydroxymethyl-3-methoxyphenoxybutyric acid linker [1].This hyperacid-sensitive resin is a useful tool for the Fmoc SPPS of protected peptide acid fragments. Attachment of carboxylic acids is normally achieved by DMAP catalyzed esterification with the appropriate symmetrical anhydride, or by using 2,6-dichlorobenzoylchloride/pyridine [2] or MSNT/Melm activation [3,4,5].Detachment of these functionalities can be effected by treatment with 1-5% TFA in DCM.
Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins
Associated Protocols and Technical Articles
Protocols for Loading of Peptide Synthesis Resins
Analysis Note
Colour (visual): white to yellow to beige
Appearance of substance (visual): beads
Loading (determined from the substitution of the Fmoc-Leu loaded resin): 0.40 - 1.00 mmol/g
Swelling Volume (in DMF): lot specific result
The polymer matrix is copoly ( styrene - 1% DVB ) 100- 200 mesh
Appearance of substance (visual): beads
Loading (determined from the substitution of the Fmoc-Leu loaded resin): 0.40 - 1.00 mmol/g
Swelling Volume (in DMF): lot specific result
The polymer matrix is copoly ( styrene - 1% DVB ) 100- 200 mesh
Other Notes
Replaces: 01-64-0036
Legal Information
Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
实验方案
Review various resins like Merrifield, trityl-based, and hydroxymethyl-functionalized for peptide immobilization for diverse applications.
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| 8550610001 | 04027269111915 |
| 8550610005 | 04027269111922 |