Fmoc-Lys(carbamate wang resin)-AMC (100-200 mesh)

A novel resin for the preparation of peptide substrates based on 3-amino-7-methylcoumarin (AMC) by Fmoc SPPS. Following Fmoc removal with 20% piperidine, peptide assembly can be effected using standard coupling methods. Treatment with 95% TFA releases the peptide-AMC directly from the solid phase.

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS

Replaces: 04-12-3917

Colour (visual): white to yellow to beige
Appearance of substance (visual): beads
Loading (Photometric determination of the Fmoc-chromophore liberated upon treatment with DBU/DMF): 0.40 - 0.60 mmol/g
Swelling Volume (in DMF): lot specific result
Identity (of the substitution): passes test
The polymer matrix is copoly (styrene - 1% DVB) 100 -200 mesh. The resin is endcapped after coupling the amino acid derivative.

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany