产品名称
抗-MMP-2抗体，催化结构域, Chemicon®, from rabbit
Gene Information
human ... MMP2(4313)
biological source
rabbit
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
polyclonal
species reactivity
human, mouse, rat
manufacturer/tradename
Chemicon®
technique(s)
immunoprecipitation (IP): suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Application
使用该抗MMP-2抗体，催化结构域，经过验证可用于IP & WB检测MMP-2。
研究子类别
MMPs & TIMPs
MMPs & TIMPs
研究类别
细胞结构
细胞结构
蛋白质印迹：1:2,000
免疫沉淀：1:500
MMP-2[明胶酶-A]在静止的细胞和组织中组成性产生，该酶对变性胶原具有高比活性。细胞培养中产生的低蛋白水平（pg/mL）通常低于标准蛋白质印迹法检测的阈值。该酶可以通过明胶-琼脂糖亲和层析（Goldberg，1992）或免疫沉淀法从培养基中浓缩。这可以防止在某些浓缩培养基显示的68 kDa附近出现抗体结合的假带。
最佳工作稀释度必须由最终用户进行确定。
免疫沉淀：1:500
MMP-2[明胶酶-A]在静止的细胞和组织中组成性产生，该酶对变性胶原具有高比活性。细胞培养中产生的低蛋白水平（pg/mL）通常低于标准蛋白质印迹法检测的阈值。该酶可以通过明胶-琼脂糖亲和层析（Goldberg，1992）或免疫沉淀法从培养基中浓缩。这可以防止在某些浓缩培养基显示的68 kDa附近出现抗体结合的假带。
最佳工作稀释度必须由最终用户进行确定。
Biochem/physiol Actions
可识别大鼠MMP-2。与其他MMP家族成员无交叉反应。 使用大肠埃希菌表达的活性大鼠72 kDa IV型胶原酶（催化结构域）作为免疫原产生抗体。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
Immunogen
使用大肠埃希菌表达的活性大鼠72 kDa IV型胶原酶（催化结构域）
表位：催化结构域
Other Notes
替代品：04-1048
浓度：请参考批次特异性浓缩物的检验报告。
Physical form
形式：纯化
纯化的免疫球蛋白。 在含0.05%叠氮化钠的PBS中的液体。
Preparation Note
以未稀释的等分形式可在2-8°C冷藏保存长达12个月。
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
John R Barbour et al.
The Journal of thoracic and cardiovascular surgery, 132(4), 788-795 (2006-09-27)
An important component of matrix remodeling during thoracic aortic aneurysm progression is the balance between matrix metalloproteinases and their endogenous inhibitors (tissue inhibitors of metalloproteinases). However, whether and to what degree matrix metalloproteinase/tissue inhibitor of metalloproteinases profiles change over time
Yu-Mei Xue et al.
Molecular medicine reports, 17(2), 3425-3431 (2017-12-20)
Atrial fibrosis is the fundamental characteristic of the structural pathology associated with atrial fibrillation (AF). Inflammation can contribute to atrial fibrosis, engendering AF. The present study aimed to investigate the role of macrophage migration inhibitory factor (MIF), a pleiotropic cytokine
Jennifer A Kwan et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 18(6), 690-692 (2004-02-10)
Matrix metalloproteinases (MMPs) are traditionally known for their role in extracellular matrix remodeling. Increasing evidence reveals several alternative substrates and novel biological roles for these proteases. Recent evidence showed the intracellular localization of MMP-2 within cardiac myocytes, colocalized with troponin
Vascular cell adhesion molecule 1 (VCAM-1) activation of endothelial cell matrix metalloproteinases: role of reactive oxygen species.
Deem, TL; Cook-Mills, JM
Blood null
Jessica M Bradley et al.
Journal of applied physiology (Bethesda, Md. : 1985), 115(7), 1099-1106 (2013-07-28)
Chronic exposure to diesel exhaust particulates (DEP) increases the risk of cardiovascular disease in urban residents, predisposing them to the development of several cardiovascular stresses, including myocardial infarctions, arrhythmias, thrombosis, and heart failure. DEP contain a high level of polycyclic
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