AB2202
抗-PER2抗体
serum, Chemicon®
别名:
Anti-FASPS, Anti-FASPS1
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
western blot
Species reactivity:
mouse, rat
Citations:
22
Technique(s):
western blot: suitable
Uniprot accession no.:
产品名称
抗-PER2抗体, serum, Chemicon®
biological source
rabbit
conjugate
unconjugated
antibody form
serum
antibody product type
primary antibodies
clone
polyclonal
species reactivity
mouse, rat
manufacturer/tradename
Chemicon®
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
mouse ... Per2(18627)
Analysis Note
对照
C2C12组织裂解液。
C2C12组织裂解液。
通过蛋白质印迹对C2C12裂解液进行了常规评估。
Application
抗PER2抗体检测PER2的水平，&经发布 & 经验证可用于WB。
研究子类别
昼夜节律 & 睡眠
昼夜节律 & 睡眠
研究类别
神经科学
神经科学
蛋白印迹分析：
通过电泳分离C2C12裂解物，转移到PVDF膜上，并用抗PER2（该批次的1:500稀释液）进行探测。使用与HRP偶联的驴抗兔二抗和化学发光检测系统可视化蛋白质。
通过电泳分离C2C12裂解物，转移到PVDF膜上，并用抗PER2（该批次的1:500稀释液）进行探测。使用与HRP偶联的驴抗兔二抗和化学发光检测系统可视化蛋白质。
Biochem/physiol Actions
与其他物种的反应性尚未确定。
目录# AB2202将识别PER2的N端。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
PER2是昼夜节律机制的组成部分，对于产生昼夜节律至关重要。它通过与其他昼夜节律调节蛋白相互作用并将其转运到细胞核来影响时钟功能，是昼夜节律转录环中的负调控元件。 PER2负调节时钟NPAS2-BMAL1 BMAL2诱导的反式激活。该基因是Period基因家族的成员，并在视交叉上核（哺乳动物脑中的主要昼夜节律起搏器）中以昼夜节律模式表达。该家族中的基因编码运动活动，代谢和行为的昼夜节律的组成部分。视交叉上核中的昼夜节律表达在恒定的黑暗中继续进行，并且明/暗周期的变化引起视交叉上核中基因表达的比例变化。该基因的特定功能尚不清楚。
根据所用的磷酸化水平和凝胶系统，肝脏产物可以在更高的200 kDa处观察到约为136 kDa的条带。
Immunogen
合成肽。
Other Notes
浓度：请参考批次特异性浓缩物的检验报告。
Physical form
含0.05% NaN3的血清
Preparation Note
自收到之日起，在-20°C以未稀释的等分试样可保存1年。
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
10 - Combustible liquids
wgk
WGK 1
Peiyuan Qiu et al.
National science review, 6(1), 87-100 (2019-01-01)
Circadian disruption is a risk factor for metabolic, psychiatric and age-related disorders, and non-human primate models could help to develop therapeutic treatments. Here, we report the generation of BMAL1 knockout cynomolgus monkeys for circadian-related disorders by CRISPR/Cas9 editing of monkey
Shell neurons of the master circadian clock coordinate the phase of tissue clocks throughout the brain and body.
Evans, JA; Suen, TC; Callif, BL; Mitchell, AS; Castanon-Cervantes, O; Baker, KM; Kloehn et al.
BMC Biology null
Youli Yao et al.
Frontiers in physiology, 11, 294-294 (2020-05-12)
Alzheimer's disease (AD) patients often exhibit perturbed circadian rhythm with fragmented sleep before disease onset. This study was designed to evaluate the effect of a 40-Hz light flicker on circadian rhythm in an AD mouse model (APP/PS1). Locomotor rhythms recordings
Jennifer Gile et al.
Current pharmaceutical design, 26(34), 4330-4337 (2020-04-16)
We recently reported a role for the circadian rhythm protein Period 2 (PER2) in midazolam induced cognitive dysfunction. Based on previous studies showing a critical role for the adenosine A2B receptor (ADORA2B) in PER2 regulation, we hypothesized that hippocampal ADORA2B
Jianwei Wang et al.
Nature cell biology, 21(6), 791-792 (2019-02-28)
In the version of this Article originally published, the authors mistakenly used the same images for the Fig. 2d Per-/- upper Merge, DAPI and p-RPA2 (Ser33), and Fig. 3e upper 2 months, WT Per2 DAPI and Merge panels. The correct
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