AB2286
Anti-Beta (β)-Amyloid antibody
CHEMICON®, rabbit polyclonal
别名:
Amyloid Fibrils, Amyloid Fibrils OC
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关于此项目
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Clone:
polyclonal
Species reactivity:
human
Application:
ELISA
dot blot
immunocytochemistry
immunohistochemistry
immunoprecipitation (IP)
western blot
dot blot
immunocytochemistry
immunohistochemistry
immunoprecipitation (IP)
western blot
Technique(s):
ELISA: suitable
dot blot: suitable
immunocytochemistry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
dot blot: suitable
immunocytochemistry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
Citations:
86
Uniprot accession no.:
产品名称
抗淀粉样蛋白原纤维OC抗体, serum, Chemicon®
biological source
rabbit
antibody form
serum
antibody product type
primary antibodies
clone
polyclonal
species reactivity
human
species reactivity (predicted by homology)
rat, mouse
manufacturer/tradename
Chemicon®
technique(s)
ELISA: suitable
dot blot: suitable
immunocytochemistry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
isotype
IgG
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... APP(351)
mouse ... App(11820)
Analysis Note
对照
阿尔茨海默病′脑组织
阿尔茨海默病′脑组织
通过斑点印迹法在单体、寡核苷酸和原纤维中进行评估。
斑点印迹分析：该抗体的1:1,000稀释液检测到单体、寡核苷酸和原纤维中的淀粉样蛋白原纤维。
斑点印迹分析：该抗体的1:1,000稀释液检测到单体、寡核苷酸和原纤维中的淀粉样蛋白原纤维。
Application
抗淀粉样原纤维OC抗体是用于IP、IC、IH、ELISA、WB、DB的抗淀粉样原纤维OC的抗体。
斑点印迹分析：该抗体的1:1,000稀释液检测到单体、寡核苷酸和原纤维中的淀粉样蛋白原纤维。
研究子类别
神经退行性疾病
神经退行性疾病
研究类别
神经科学
神经科学
Biochem/physiol Actions
该抗体识别许多淀粉样蛋白原纤维和原纤维寡聚体共有的通用表位，但不能识别原纤维寡聚体或天然折叠蛋白。 它也可能显示出对Aβ单体的弱反应性，而AB2287则没有。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
淀粉样蛋白单体蛋白有时可以寡聚为破坏性淀粉样蛋白原纤维。非疾病相关蛋白的淀粉样蛋白构象可以通过部分蛋白错误折叠或变性产生。在疾病状态的寡聚化中，广泛的淀粉样蛋白寡聚化会在神经组织中形成与阿尔茨海默氏症’相关的斑块。
Immunogen
由人Aß42肽制备的原纤维。
Physical form
含0.05％叠氮化钠的未纯化兔多克隆抗体血清。
未纯化
Preparation Note
自收到之日起在-20°C可稳定保存1年。
使用建议：收到后，在取下瓶盖之前，将小瓶离心并轻轻混合溶液。分装到微量离心管中，并储存于 -20°C。避免反复冻融循环，以免损坏 IgG 和影响产品性能。
使用建议：收到后，在取下瓶盖之前，将小瓶离心并轻轻混合溶液。分装到微量离心管中，并储存于 -20°C。避免反复冻融循环，以免损坏 IgG 和影响产品性能。
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
10 - Combustible liquids
wgk
WGK 1
Rosa Sánchez et al.
Scientific reports, 6, 32801-32801 (2016-09-07)
Amyloids are polymeric structural states formed from locally or totally unfolded protein chains that permit surface reorganizations, stability enhancements and interaction properties that are absent in the precursor monomers. β-Parvalbumin, the major allergen in fish allergy, forms amyloids that are
Peng Liu et al.
Cell reports, 11(11), 1760-1771 (2015-06-09)
The accumulation of amyloid-β (Aβ) as amyloid fibrils and toxic oligomers is an important step in the development of Alzheimer's disease (AD). However, there are numerous potentially toxic oligomers and little is known about their neurological effects when generated in
Sofia B Carvalho et al.
PloS one, 8(10), e76629-e76629 (2013-10-08)
S100 proteins are small dimeric calcium-binding proteins which control cell cycle, growth and differentiation via interactions with different target proteins. Intrinsic disorder is a hallmark among many signaling proteins and S100 proteins have been proposed to contain disorder-prone regions. Interestingly
Michael H Hayes et al.
Biology open, 5(6), 801-806 (2016-05-25)
A hallmark of Alzheimer's, Huntington's and similar diseases is the assembly of proteins into amyloids rather than folding into their native state. There is an increasing appreciation that amyloids, under specific conditions, may be non-pathogenic. Here we show that amyloids
Functional amyloids in the mouse sperm acrosome.
Guyonnet, B; Egge, N; Cornwall, GA
Molecular and cellular biology null
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