AB3092
抗促食欲素-1受体抗体
Chemicon®, from rabbit
别名:
OX1R, Hypocretin Receptor 1
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA
western blot
western blot
Species reactivity:
rat, human, mouse
Citations:
7
Technique(s):
ELISA: suitable
western blot: suitable
western blot: suitable
Uniprot accession no.:
产品名称
抗促食欲素-1受体抗体, Chemicon®, from rabbit
biological source
rabbit
conjugate
unconjugated
antibody form
affinity purified immunoglobulin
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
rat, human, mouse
manufacturer/tradename
Chemicon®
technique(s)
ELISA: suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... HCRTR1(3061)
Analysis Note
对照
下丘脑
下丘脑
Application
研究子类别
代谢的CNS控制
昼夜节律性&睡眠
代谢的CNS控制
昼夜节律性&睡眠
研究类别
神经科学
神经科学
蛋白质印迹：使用化学发光技术为1-10μg/mL。 蛋白在45-48 kDa运行。
ELISA：1：10,000-1：100,000用于50-100 ng/wel免疫原肽。
最佳工作稀释度必须由最终用户进行确定。
ELISA：1：10,000-1：100,000用于50-100 ng/wel免疫原肽。
最佳工作稀释度必须由最终用户进行确定。
该抗食欲素-1受体抗体经过验证可用在 ELISA，WB中检测食欲素-1受体。
Biochem/physiol Actions
可识别大鼠和人食欲素-1。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
45-48kda
最近已经报告了几种与进食行为有关的肽。 食欲素（食欲素-A和食欲素-B）是在下丘脑中选择性表达的下丘脑神经肽家族（Sakurai et al.1998）。 食欲素-A和食欲素-B通过蛋白水解裂解衍生自相同的前体（前体-食欲素）。 前体食欲素是一种130 aa的肽，具有假定的33 aa分泌序列，疏水核心，其后是带有小极性侧链的残基。 在脑中检测到该表达，在睾丸中检测到很小程度的表达（Sakurai et al.1998）。 这些神经肽结合并激活两个密切相关的食欲素受体-G蛋白偶联受体（GPCR）OX1R和OX2R。
Immunogen
大鼠OX1R N末端附近的16 aa肽和人OX1R C末端附近的16 aa肽。
Other Notes
浓度：请参考批次特异性浓缩物的分析证书。
Physical form
亲和纯化的免疫球蛋白。含0.1%BSA的PBS液体。
免疫亲和纯化
Preparation Note
自装运之日起在-20°C可保存6个月。避免反复冻融。为了最大程度地回收产品，在融化后和取下盖子之前，将原始样品瓶进行离心。
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Xianglong Meng et al.
American journal of translational research, 9(4), 1774-1782 (2017-05-05)
The mesenchymal stem cell (MSC) shows potential in degenerative disc disease (DDD) treatment. However, little is known about the function of heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1) in modulating the chondrogenic differentiation of MSCs. This study aimed to investigate the role
Konstantina Vraka et al.
Biomolecules, 13(4) (2023-05-16)
The orexin system is related to food behavior, energy balance, wakefulness and the reward system. It consists of the neuropeptides orexin A and B, and their receptors, orexin 1 receptor (OX1R) and orexin 2 receptor (OX2R). OX1R has selective affinity
Israt Z Shahid et al.
British journal of pharmacology, 165(7), 2292-2303 (2011-09-29)
The rostral ventrolateral medulla (RVLM) maintains sympathetic nerve activity (SNA), and integrates adaptive reflexes. Orexin A-immunoreactive neurones in the lateral hypothalamus project to the RVLM. Microinjection of orexin A into RVLM increases blood pressure and heart rate. However, the expression
Sheng-Lian Yang et al.
Protein & cell, 3(12), 934-942 (2012-11-20)
Articular cartilage, which is mainly composed of collagen II, enables smooth skeletal movement. Degeneration of collagen II can be caused by various events, such as injury, but degeneration especially increases over the course of normal aging. Unfortunately, the body does
Chung-Wei Hsu et al.
Brain sciences, 11(12) (2021-12-25)
Orexin-A (OX-A) and orexin-B (OX-B) are neuropeptides produced in the hypothalamus. Preclinical and clinical studies suggest that depression and anxiety are associated with the orexin system. In the current study, we used the learned helplessness (LH) animal model of depression
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