AB3094
抗促食欲素-2受体抗体
Chemicon®, from rabbit
别名:
OX2R, Hypocretin Receptor 2
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Species reactivity:
mouse, rat, human
Citations:
9
Technique(s):
ELISA: suitable
immunohistochemistry: suitable
western blot: suitable
immunohistochemistry: suitable
western blot: suitable
Uniprot accession no.:
产品名称
抗促食欲素-2受体抗体, Chemicon®, from rabbit
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
mouse, rat, human
manufacturer/tradename
Chemicon®
technique(s)
ELISA: suitable
immunohistochemistry: suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... HCRTR2(3062)
Application
使用经验证可用于ELISA、IH&WB的抗食欲素-2受体抗体检测食欲素-2受体。
研究子类别
代谢的CNS控制
昼夜节律性&睡眠
代谢的CNS控制
昼夜节律性&睡眠
研究类别
神经科学
神经科学
蛋白质印迹：使用化学发光技术为1-10μg/mL
ELISA：对照肽（目录号AG794）的1：10,000-100,000。
最佳工作稀释度必须由最终用户进行确定。
ELISA：对照肽（目录号AG794）的1：10,000-100,000。
最佳工作稀释度必须由最终用户进行确定。
Biochem/physiol Actions
大鼠/人食欲素-2。 最近已经报告了几种与进食行为有关的肽。 食欲素（食欲素-A和食欲素-B）是在下丘脑中选择性表达的下丘脑神经肽家族（Sakurai et al.1998）。 食欲素-A和食欲素-B通过蛋白水解裂解衍生自相同的前体（前体-食欲素）。 前体食欲素是一种130 aa的肽，具有假定的33 aa分泌序列，疏水核心，其后是带有小极性侧链的残基。 在脑中检测到该表达，在睾丸中检测到很小程度的表达（Sakurai et al.1998）。 这些神经肽结合并激活两个密切相关的食欲素受体-G蛋白偶联受体（GPCR）OX1R和OX2R。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
Immunogen
大鼠OX2R C末端（细胞质域）附近的19个aa 肽。 免疫原肽（目录号AG794）可用于进行预吸收对照。
Other Notes
浓度：请参考批次特异性浓缩物的分析证书。
Physical form
亲和纯化的1mg/ml溶液，溶于PBS、pH值7.4和0.1%BSA中
Preparation Note
自收到之日起，在 -20°C 以未稀释的等分试样可保存 6 个月。 应避免反复冻/融循环。
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Caterina Squillacioti et al.
Frontiers in veterinary science, 9, 880022-880022 (2022-07-30)
Orexins A (OXA) and B (OXB) and the receptors 1 (OX1R) and 2 (OX2R) for orexins are hypothalamic peptides found in several mammalian organs and participated to the control of a wide assortment of physiological and pathological functions. The distribution
Krister Melén et al.
Journal of translational autoimmunity, 3, 100055-100055 (2020-08-04)
Narcolepsy type 1, likely an immune-mediated disease, is characterized by excessive daytime sleepiness and cataplexy. The disease is strongly associated with human leukocyte antigen (HLA) DQB1∗06:02. A significant increase in the incidence of childhood and adolescent narcolepsy was observed after
P Dehan et al.
The Journal of clinical endocrinology and metabolism, 98(4), 1549-1557 (2013-03-14)
Orexins A and B are neuropeptides that bind and activate 2 types of receptors. In addition to direct action in the brain, the orexinergic system has broader implications in peripheral organs, and it has been proposed to have a role
Qin-Qin Wang et al.
Cellular signalling, 54, 46-58 (2018-11-28)
As G-protein-coupled receptors (GPCRs), 5-hydroxytryptamine 1A receptor (5-HT1AR) and orexin receptor 2 (OX2R) regulate the levels of the cellular downstream molecules. The heterodimers of different GPCRs play important roles in various of neurological diseases. Moreover, 5-HT1AR and OX2R are involved
Chung-Wei Hsu et al.
Brain sciences, 11(12) (2021-12-25)
Orexin-A (OX-A) and orexin-B (OX-B) are neuropeptides produced in the hypothalamus. Preclinical and clinical studies suggest that depression and anxiety are associated with the orexin system. In the current study, we used the learned helplessness (LH) animal model of depression
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