产品名称
抗单羧酸转运蛋白4抗体, Chemicon®, from rabbit
biological source
rabbit
conjugate
unconjugated
antibody form
affinity purified immunoglobulin
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
rat
manufacturer/tradename
Chemicon®
technique(s)
ELISA: suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... SLC16A3(9123)
Application
使用经验证可用于ELISA &WB的抗单羧酸转运蛋白4抗体检测单羧酸转运蛋白4。
研究子类别
离子通道 & 转运体
离子通道 & 转运体
研究类别
神经科学
神经科学
蛋白质印迹：使用ECL为1-5 mg/mL。
ELISA：1：10,000-1：100,000，每孔使用50-100 ng对照肽。
最佳工作稀释度必须由最终用户进行确定。
ELISA：1：10,000-1：100,000，每孔使用50-100 ng对照肽。
最佳工作稀释度必须由最终用户进行确定。
Biochem/physiol Actions
识别大鼠单羧酸转运蛋白4（MCT4/MOT4/SLC16A3）。 免疫原与其他MCT没有明显的序列同源性。 MCT4在骨骼肌和其他具有高糖酵解率的细胞（例如肿瘤细胞和白细胞）中显著表达，表明其在乳酸外排中起重要作用。
注意： 根据新的命名法，旧的MCT3现在已重新分类为MCT4。 请查阅Halestrap和Price（1999）Biochem.J. 343:281-299.
物种反应性：
大鼠。 免疫原序列在人和小鼠中100%保守，在鸡中78%保守。 与其他物种的反应性尚未得到确认。
注意： 根据新的命名法，旧的MCT3现在已重新分类为MCT4。 请查阅Halestrap和Price（1999）Biochem.J. 343:281-299.
物种反应性：
大鼠。 免疫原序列在人和小鼠中100%保守，在鸡中78%保守。 与其他物种的反应性尚未得到确认。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
Immunogen
大鼠/人/小鼠MCT4 C末端附近的19个氨基酸的肽序列。
Other Notes
替代品：AB3546P
浓度：请参考批次特异性浓缩物的分析证书。
Physical form
亲和纯化的免疫球蛋白。 含0.1%BSA和0.05%叠氮化钠的PBS液体。
Preparation Note
自收到之日起，在 -20°C 以未稀释的等分试样可保存 6 个月。 应避免反复冻/融循环。
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Claire Thomas et al.
American journal of physiology. Endocrinology and metabolism, 293(4), E916-E922 (2007-07-05)
This study investigated the effects of high-intensity training, with or without induced metabolic alkalosis, on lactate transporter (MCT1 and MCT4) and sodium bicarbonate cotransporter (NBC) content in rat skeletal muscles. Male Wistar rats performed high-intensity training on a treadmill 5
Jieyun Cao et al.
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 20(1), 435-444 (2017-12-19)
Monocarboxylate transporters (MCTs) are involved in the transport of monocarboxylates such as ketone bodies, lactate, and pharmaceutical agents. CD147 functions as an ancillary protein for MCT1 and MCT4 for plasma membrane trafficking. Sex differences in MCT1 and MCT4 have been
A Nagai et al.
Placenta, 31(2), 126-133 (2009-12-22)
Lactate plays an important role as an alternative energy substrate, especially in conditions with a decreased utility of glucose. Proton-coupled monocarboxylate transporters (MCTs) are essential for the transport of lactate, ketone bodies, and other monocarboxylates through the plasma membrane and
T T Yohe et al.
Journal of dairy science, 102(9), 8502-8512 (2019-07-08)
Diet is known to affect rumen growth and development. Calves fed an all-liquid diet have smaller and less developed rumens and a decreased ability to absorb volatile fatty acids (VFA) compared to calves fed both liquid and dry feed. However
Zohra Benyahia et al.
Cancers, 13(3) (2021-02-06)
To survive and proliferate in solid tumors, cancer cells adapt and evolve rapidly in microenvironments where oxygen and substrate bioavailability fluctuates over time and space. This creates metabolic heterogeneity. Cancer cells can further cooperate metabolically, for example by swapping glycolytic
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