AB3316P
抗单羧酸转运蛋白4抗体
Chemicon®, from rabbit
别名:
MCT4
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA
western blot
western blot
Species reactivity:
human
Citations:
42
Technique(s):
ELISA: suitable
western blot: suitable
western blot: suitable
Uniprot accession no.:
产品名称
抗单羧酸转运蛋白4抗体, Chemicon®, from rabbit
biological source
rabbit
conjugate
unconjugated
antibody form
affinity purified immunoglobulin
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
human
manufacturer/tradename
Chemicon®
technique(s)
ELISA: suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... SLC16A3(9123)
Application
抗单羧酸转运蛋白4抗体可检测单羧酸转运蛋白4的水平&已发表&经验证可用于ELISA& WB。
研究子类别
离子通道 & 转运体
离子通道 & 转运体
研究类别
神经科学
神经科学
蛋白质印迹：使用ECL为1-5μg/mL
免疫组化：未检验。推荐的抗体检验稀释度：在多聚甲醛固定组织上为5-10 μg/mL。
ELISA：1：10,000-1：100,000，每孔使用50-100 ng对照肽（目录号AG219）。
最佳工作稀释度必须由最终用户进行确定。
免疫组化：未检验。推荐的抗体检验稀释度：在多聚甲醛固定组织上为5-10 μg/mL。
ELISA：1：10,000-1：100,000，每孔使用50-100 ng对照肽（目录号AG219）。
最佳工作稀释度必须由最终用户进行确定。
Biochem/physiol Actions
识别人单羧酸转运蛋白4（MCT4）。 免疫原与其他MCT没有明显的序列同源性。MCT4在骨骼肌和其他具有高糖酵解率的细胞（例如肿瘤细胞和白细胞）中显著表达，表明其在乳酸外排中起重要作用。
注意：根据新的命名法，旧的MCT3现在已重新分类为MCT4。 请查阅Halestrap和Price（1999）Biochem.J. 343:281-299.
注意：根据新的命名法，旧的MCT3现在已重新分类为MCT4。 请查阅Halestrap和Price（1999）Biochem.J. 343:281-299.
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
Immunogen
人MCT4胞质结构域#4内的19个氨基酸肽序列（Wilson et al., 1998; Price et al., 1998).
Other Notes
替代品：AB3548P
浓度：请参考批次特异性浓缩物的分析证书。
Physical form
亲和纯化的免疫球蛋白。 含0.1%BSA的PBS液体。
Preparation Note
自收到之日起，在 -20°C 以未稀释的等分试样可保存 6 个月。 应避免反复冻/融循环。
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Céline Pinheiro et al.
Virchows Archiv : an international journal of pathology, 452(2), 139-146 (2008-01-12)
Tumour cells are known to be highly glycolytic, thus producing high amounts of lactic acid. Monocarboxylate transporters (MCTs), by promoting the efflux of the accumulating acids, constitute one of the most important mechanisms in the maintenance of tumour intracellular pH.
Yi-Chen Sun et al.
Investigative ophthalmology & visual science, 58(9), 3716-3722 (2017-07-25)
To determine the presence of monocarboxylate transporter (MCT) in human and rabbit corneal epithelium and its role in transcellular fluorescein transportation in the cornea. The presence of MCTs in human and rabbit corneal epithelium was determined by RT-PCR and immunohistochemistry.
Importance of pH regulation and lactate/H+ transport capacity for work production during supramaximal exercise in humans.
Messonnier, L; Kristensen, M; Juel, C; Denis, C
Journal of Applied Physiology (1985)
Stefan De Smet et al.
Frontiers in physiology, 8, 347-347 (2017-06-18)
In the setting of "living high," it is unclear whether high-intensity interval training (HIIT) should be performed "low" or "high" to stimulate muscular and performance adaptations. Therefore, 10 physically active males participated in a 5-week "live high-train low or high"
Cian McGinley et al.
Experimental physiology, 101(12), 1565-1580 (2016-10-01)
What is the central question of this study? Following a training intervention, how is the interpretation of adaptations in skeletal muscle H+ transporters influenced by biopsy timing in the context of individual protein and mRNA kinetics after the final exercise
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