AB3420-I
抗表面活性物质蛋白A抗体
from rabbit
别名:
Pulmonary surfactant-associated protein A1, PSP-A, PSPA, SP-A, SP-A1, 35 kDa pulmonary surfactant-associated protein, Alveolar proteinosis protein, Collectin-4
产品名称
抗表面活性物质蛋白A抗体, from rabbit
biological source
rabbit
conjugate
unconjugated
antibody form
purified antibody
antibody product type
primary antibodies
clone
polyclonal
species reactivity
human, mouse
species reactivity (predicted by homology)
primate (based on 100% sequence homology)
technique(s)
immunohistochemistry: suitable (paraffin)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... SFTPA1(653509)
mouse ... Sftpd(20390)
Analysis Note
对照
人肺组织裂解液
人肺组织裂解液
通过蛋白质印迹对人肺组织裂解液进行了评估。
蛋白质印迹分析：0.5 µg/mL该抗体在10 µg人肺组织裂解液中检测到表面活性物质蛋白A。
蛋白质印迹分析：0.5 µg/mL该抗体在10 µg人肺组织裂解液中检测到表面活性物质蛋白A。
Application
使用经验证可用于蛋白质印迹&IHC（石蜡）的兔多克隆抗体，抗表面活性物质蛋白A抗体检测SP-A。
免疫组化分析：代表性批次的1：200的稀释液在人肺组织中检测到表面活性物质蛋白A。
研究子类别
发育信号转导
发育信号转导
研究类别
神经科学
神经科学
Biochem/physiol Actions
其他同源性：Uniprot与大鼠没有同源性。
该抗体可识别表面活性物质蛋白A的C型凝集素结构域。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
肺表面活性物质相关蛋白A1（SP-A1，SFTPA1，PSP-A，SP-A）与表面活性剂磷脂结合，并有助于降低哺乳动物肺泡气液界面的表面张力，对于正常呼吸是必需的。有四种主要的表面活性物质蛋白，分别称为SP-A，B，C和D。SP-A是第一个被鉴别的表面活性物质蛋白，也是最丰富的。其分子质量范围为26-38kDa。根据系统中存在的其他物质，它可以以开放或封闭的形式找到。钙产生封闭的花束形式。SP-A对于产生管状髓磷脂（一种肺特有的脂质运输结构）是必需的。SP-A的遗传变异是早产儿易患特发性肺纤维化（IPF）和呼吸窘迫综合征（RDS）的原因。
观察值〜35 kDa
Immunogen
KLH偶联的线性肽，对应于人表面活性物质蛋白A的C型凝集素结构域。
表位：C型凝集素结构域
Other Notes
替代品：AB3420
浓度：请参考批次特异性浓缩物的分析证书。
Physical form
在含 0.1 M Tris-甘氨酸（pH 7.4），150 mM NaCl 和 0.05％ 叠氮化钠的缓冲液中的纯化的兔多克隆抗体。
形式：纯化
纯化的蛋白 A
Preparation Note
自收到之日起，在 2-8°C 条件下可稳定保存1年
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
M Neuhaus et al.
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International journal of legal medicine, 133(5), 1461-1467 (2019-06-22)
The diagnosis of drowning is one of the most difficult in forensic medicine. The aim of this study was to analyze pulmonary tissue reactions in death by drowning. In particular, we focused on the immunohistochemical expression of P-selectin, SP-A, HSP70
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Development of effective treatment strategies for lung tissue destruction as seen in emphysema would greatly benefit from representative human in vitro models of the alveolar compartment. Studying how cellular cross talk and/or (altered) biomechanical cues affect alveolar epithelial function could
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