AB3607
抗-ASC抗体
Chemicon®, from rabbit
别名:
TMS1, CARD5, Apoptosis-associated Speck-like Protein containing a CARD
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
western blot
Species reactivity:
human
Citations:
10
Technique(s):
western blot: suitable
Uniprot accession no.:
产品名称
抗-ASC抗体, Chemicon®, from rabbit
biological source
rabbit
conjugate
unconjugated
antibody form
affinity purified immunoglobulin
antibody product type
primary antibodies
clone
polyclonal
species reactivity
human
manufacturer/tradename
Chemicon®
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Application
研究子类别
凋亡-附加
凋亡-附加
研究类别
细胞凋亡 & 癌症
细胞凋亡 & 癌症
蛋白质印迹：1：500
HL60全细胞裂解液可作为阳性对照。
最佳工作稀释度必须由最终用户进行确定。
HL60全细胞裂解液可作为阳性对照。
最佳工作稀释度必须由最终用户进行确定。
该抗ASC抗体经过验证可用于WB检测ASC。
Biochem/physiol Actions
通过蛋白质印迹检测对应于ASC/TMS1的25 kDa条带。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
凋亡受包含分子和蛋白酶的胱天蛋白酶家族的死亡结构域（DD）和/或胱天蛋白酶募集结构域（CARD）调节。 含有细胞死亡调节剂的CARD包括RAIDD，RICK，Bcl10，Apaf-1，ARC，胱天蛋白酶-2和胱天蛋白酶-9。 已经在人和小鼠中鉴别出含有蛋白的新型CARD结构域，并将其命名为ASC和TMS1。 ASC/TMS1的异位表达通过激活胱天蛋白酶-9诱导凋亡并抑制人乳腺癌细胞的存活。 ASC/TMS1的过表达诱导DNA断裂。 ASC/TMS1在多种人类和小鼠组织中表达。
Immunogen
对应于人ASC的aa 182-195（RESQSYLVEDLERS）的肽。
Other Notes
浓度：请参考批次特异性浓缩物的分析证书。
Physical form
亲和纯化的免疫球蛋白。 含0.02%叠氮化钠的PBS液体。
形式：纯化
Preparation Note
在4°C下可保存长达6个月。
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Rekha R Garg et al.
The Journal of biological chemistry, 294(21), 8480-8489 (2019-04-04)
Among the repertoire of immunoregulatory proteins encoded by myxoma virus, M013 is a viral homologue of the viral pyrin domain-only protein (vPOP) family. In myeloid cells, M013 protein has been shown to inhibit both the inflammasome and NF-κB signaling pathways
Jie Zhao et al.
Journal of Crohn's & colitis, 15(4), 647-664 (2020-10-07)
Crohn's disease [CD] is a chronic, relapsing and incurable inflammatory disorder. Micro RNAs [miRNAs], which modulate gene expression by binding to mRNAs, may make significant contributions to understanding the complex pathobiology and aetiology of CD. This study aimed to investigate
Y Xing et al.
Cell death & disease, 7(8), e2322-e2322 (2016-08-05)
Autophagosomes derived from tumor cells, also referred to as defective ribosomal products in blebs (DRibbles), have been previously shown to stimulate potent T-cell responses and mediate tumor regression when used as therapeutic cancer vaccines in multiple preclinical cancer models. In
Yunchao Shi et al.
Brain and behavior, 13(5), e2980-e2980 (2023-03-30)
Cognitive impairment is a critical complication of acute respiratory distress syndrome (ARDS). However, effective interventions are lacking. Growing evidence demonstrates that c-Jun N-terminal kinase (JNK)-mediated neuroinflammation is involved in the development of ARDS. Therefore, we hypothesized that the JNK pathway
Epstein-Barr virus-induced epigenetic alterations following transient infection.
Queen, KJ; Shi, M; Zhang, F; Cvek, U; Scott, RS
International Journal of Cancer. Journal International Du Cancer null
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