产品名称
IP3受体3抗体, serum, Chemicon®
biological source
rabbit
conjugate
unconjugated
antibody form
serum
antibody product type
primary antibodies
clone
polyclonal
species reactivity
mouse, rat, human
manufacturer/tradename
Chemicon®
technique(s)
immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... ITPR3(3710)
mouse ... Itpr3(16440)
rat ... Itpr3(25679)
Analysis Note
对照
蛋白质印迹 = 成年小鼠胰腺。
IHC = 成年小鼠肝细胞（成年小鼠小脑颗粒细胞为阴性）。
蛋白质印迹 = 成年小鼠胰腺。
IHC = 成年小鼠肝细胞（成年小鼠小脑颗粒细胞为阴性）。
Application
IP3受体3抗体可检测IP3受体水平 & 已发表 & 经验证可用于IC、IH & WB。
研究子类别
脂质信号转导
脂质信号转导
研究类别
信号传导
信号传导
蛋白质印迹：使用ECL为1：1,000。该抗体可与250 kDa的IP3受体3蛋白反应。建议的封闭缓冲液为10%正常山羊血清（或与你的二抗相同的宿主），1%BSA的含0.05%吐温20的0.1 M PBS。建议的稀释缓冲液为1%正常山羊血清（或与你的二抗相同的宿主），1%BSA的含0.05%吐温20的0.1 M PBS。优选的凝胶百分比是4-12%梯度凝胶。
免疫细胞化学：1：1,000
免疫组化：使用荧光标记的二抗在2-8°C下以1：1,000过夜。建议的固定剂是0.1 M PBS中的4%多聚甲醛（一小时）。建议的透化方法是0.05%Triton X-100稀释缓冲液。建议的封闭缓冲液为10%正常山羊血清（或与你的二抗相同的宿主）和1%BSA的0.1 M PBS。建议的稀释缓冲液为1%正常山羊血清（或与你的二抗相同的宿主）和1%BSA的0.1 M PBS。
最佳工作稀释度必须由最终用户进行确定。
免疫细胞化学：1：1,000
免疫组化：使用荧光标记的二抗在2-8°C下以1：1,000过夜。建议的固定剂是0.1 M PBS中的4%多聚甲醛（一小时）。建议的透化方法是0.05%Triton X-100稀释缓冲液。建议的封闭缓冲液为10%正常山羊血清（或与你的二抗相同的宿主）和1%BSA的0.1 M PBS。建议的稀释缓冲液为1%正常山羊血清（或与你的二抗相同的宿主）和1%BSA的0.1 M PBS。
最佳工作稀释度必须由最终用户进行确定。
Biochem/physiol Actions
IP3受体3。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
Immunogen
来自大鼠IP3受体3 C端的合成肽。
Physical form
兔血清。 液体。
Preparation Note
自收到之日起，在 -20°C 以未稀释的等分试样可保存 6 个月。应避免反复冻/融循环。
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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Pancreatic protease activation by alcohol metabolite depends on Ca2+ release via acid store IP3 receptors.
Gerasimenko, JV; Lur, G; Sherwood, MW; Ebisui, E; Tepikin, AV; Mikoshiba, K; Gerasimenko et al.
Proceedings of the National Academy of Sciences of the USA null
Sofia Håglin et al.
Bio-protocol, 11(8), e3983-e3983 (2021-06-15)
Odor-detecting olfactory sensory neurons residing in the nasal olfactory epithelium (OE) are the only neurons in direct contact with the external environment. As a result, these neurons are subjected to chemical, physical, and infectious insults, which may be the underlying
S Kaja et al.
Neuroscience, 175, 281-291 (2010-11-16)
Dysregulation of Ca(2+) signaling following oxidative stress is an important pathophysiological mechanism of many chronic neurodegenerative disorders, including Alzheimer's disease, age-related macular degeneration, glaucomatous and diabetic retinopathies. However, the underlying mechanisms of disturbed intracellular Ca(2+) signaling remain largely unknown. We
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