ABE364
抗-Tet2抗体
from rabbit, purified by affinity chromatography
别名:
Methylcytosine dioxygenase TET2
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ICC, IHC, WB
Citations:
15
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
mouse, human, rat
technique(s)
immunocytochemistry: suitable, immunohistochemistry: suitable (paraffin), western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... TET2(54790)
General description
甲基胞嘧啶双加氧酶TET2催化甲基胞嘧啶（5mC）向5-羟甲基胞嘧啶（5hmC）的转化。目前尚不清楚5-羟甲基胞嘧啶的功能，但它可能影响染色质结构，或充当胞嘧啶去甲基化的中间成分。TET2在骨髓增生性疾病（MPD）或骨髓增生性肿瘤（MPN）和全身性肥大细胞增生症中经常发生突变。TET2紊乱还会导致真性红细胞增多症（PV）和骨髓异常增生综合征（MDS）。
观察值〜140 kDa。已知存在223 kDa（亚型1），133 kDa（亚型2）和133 kDa（亚型3）的三个亚型。该抗体应基于序列同源性识别全部三种亚型。在某些细胞裂解物中，在〜36 kDa处可能观察到未表征的条带。（注意：亚型2和3可能在低浓度下观察到，而亚型1可能在某些细胞裂解物中以较高浓度检测到。）
Immunogen
KLH偶联线性肽对应于人Tet2。
Application
免疫组化分析：代表性批次的1：4,000稀释液在鼠髓质组织中检测到Tet2。
免疫细胞化学分析：代表性批次的1：100稀释液在人H9胚胎干细胞中检测到Tet2。
免疫细胞化学分析：代表性批次的1：100稀释液在人H9胚胎干细胞中检测到Tet2。
抗-Tet2可检测Tet2蛋白的水平&已发表&经验证可用于WB，IHC& ICC。
Analysis Note
通过蛋白质印迹在小鼠胚胎干细胞中进行了评估。
蛋白质印迹分析：1 µg/mL该抗体在10 µg小鼠胚胎干细胞中检测到Tet2。（注意：在低浓度或更长暴露时间下可观察到亚型2和3，而在某些细胞裂解液中可在更高浓度或更长暴露时间下检测到亚型1）。
蛋白质印迹分析：1 µg/mL该抗体在10 µg小鼠胚胎干细胞中检测到Tet2。（注意：在低浓度或更长暴露时间下可观察到亚型2和3，而在某些细胞裂解液中可在更高浓度或更长暴露时间下检测到亚型1）。
Other Notes
浓度：请参考批次特异性浓缩物的分析证书。
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Yun Liu et al.
Molecular pain, 18, 17448069221143671-17448069221143671 (2022-11-23)
DNA hydroxylation catalyzed by Tet dioxygenases occurs abundantly in neurons in mammals. However, effects of ten-eleven translocation methylcytosine dioxygenase 1 (TET1) expression and hydroxymethylation status on neuron injury remain unclear. This study was designed to explore the effects of TET1
Yunpeng Zhang et al.
Evidence-based complementary and alternative medicine : eCAM, 2019, 1282085-1282085 (2019-11-28)
In addition to abnormalities of motor and posture, children with cerebral palsy (CP) often have intellectual disability. As a complementary and alternative traditional Chinese medicine (TCM) therapy, Chinese Tuina massage, also called Tuina in China, has been widely applied in
Sherry X Yang et al.
Journal of hematology & oncology, 14(1), 83-83 (2021-05-28)
Challenges remain on the selection of patients who potentially respond to a class of drugs that target epigenetics for cancer treatment. This study aims to investigate TET2/DNMT3A mutations and antitumor activity of a novel epigenetic agent in multiple human cancer
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| ABE364 | 04053252859533 |