ABE52

抗细胞周期素D抗体

Name: 抗细胞周期素D抗体
Brand: MM

from rabbit, purified by affinity chromatography

别名:

B-cell CLL/lymphoma 1, BCL-1 oncogene, G1/S-specific cyclin D1, PRAD1 oncogene, cyclin D1, cyclin D1 (PRAD1: parathyroid adenomatosis 1)

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关于此项目

UNSPSC Code:

12352203

NACRES:

NA.41

eCl@ss:

32160702

Conjugate:

unconjugated

Clone:

polyclonal

Application:

immunocytochemistry
immunoprecipitation (IP)
western blot

Species reactivity:

human, mouse

Citations:

Technique(s):

immunocytochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

Uniprot accession no.:

P24385

主要文件

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产品名称

抗细胞周期素D抗体, from rabbit, purified by affinity chromatography

antibody form

affinity isolated antibody

antibody product type

primary antibodies

biological source

rabbit

conjugate

unconjugated

clone

polyclonal

purified by

affinity chromatography

species reactivity

human, mouse

species reactivity (predicted by homology)

primate (based on 100% sequence homology)

technique(s)

immunocytochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

NCBI accession no.

NP_444284.1

UniProt accession no.

P24385

shipped in

wet ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... CCND1(595)

Analysis Note

对照
3T3/A31 细胞裂解液

通过蛋白质印迹在3T3/A31细胞裂解液中进行了评估。

蛋白质印迹分析：1 µg/mL的该抗体在10 µg 3T3/A31细胞裂解液中检测到细胞周期素D。

Application

使用在 WB、ICC、IP中验证过的抗细胞周期素D 抗体（兔多克隆抗体）来检测细胞周期素D ，也称为B细胞CLL/淋巴瘤1、BCL-1致癌基因。

研究子类别
细胞周期，DNA 复制&修复

研究类别
表观遗传学&核功能

蛋白质印迹（SNAP ID）分析：一个先前批次的5 µg/mL 抗体在 10 µg 3T3/A31细胞裂解液中检测到细胞周期素D。

免疫细胞化学分析：一个先前批次的1：500稀释液在NIH/3T3、A431、C2C12和 HeLa细胞中检测到细胞周期素D。

Biochem/physiol Actions

该抗体从C末端识别细胞周期素D1。

Disclaimer

除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

General description

约34 kDa

细胞分裂周期中G1期的进展以及G1向S期的转变受到一系列不同丝氨酸/苏氨酸激酶复合物激活的控制，这些复合物包括细胞周期素调节亚基和细胞周期素依赖性激酶（cdk）。D型细胞周期素在G1期的诱发早于细胞周期素E，并可与cdk2、-4、-5和 -6形成复合物。在G1期细胞周期素D1是一种核蛋白，在S期在细胞核中消失。在关键细胞周期调节剂中，细胞周期素D1作为原癌基因与多种人类癌症（包括乳腺癌）有最深刻的联系。

Immunogen

对应于人细胞周期素D1 C末端的KLH偶联线性肽。

表位：C端

Other Notes

替代：04-221

浓度：请参考批次特异性浓缩物的检验报告。

Physical form

亲和纯化

纯化的兔多克隆抗体，溶于含有0.1 M Tris-甘氨酸（pH 7.4）、150 mM NaCl和0.05％叠氮化钠的缓冲液中。

Preparation Note

自收到之日起，在2-8°C条件下可稳定保存1年。

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存储类别

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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Dickkopf Wnt signaling pathway inhibitor 1 regulates the differentiation of mouse embryonic stem cells in vitro and in vivo.

Liping Ou et al.

Molecular medicine reports, 13(1), 720-730 (2015-12-10)

Embryonic stem cells (ESCs) are pluripotent stem cells derived from early stage embryos. It remains unclear whether inhibiting the Wnt/β‑catenin signaling pathway using dickkopf Wnt signaling pathway inhibitor 1 (DKK1) impacts on the differentiation potential of mouse ESCs in vitro

Regulation of Interferon-β-Modified Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes in Proliferation and Apoptosis of Prostate Cancer Cells.

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Prostate cancer (PCa) poses a serious burden to men. Interferon-β (IFN-β) is implicated in cancer cell growth. This study hence explored the regulation of IFN-β-modified human umbilical cord mesenchymal stem cell-derived exosomes (hUCMSC-Exos) in PCa cells. In vitro-cultured hUCMSCs were

Incomplete Recovery from the Radiocontrast-Induced Dysregulated Cell Cycle, Adhesion, and Fibrogenesis in Renal Tubular Cells after Radiocontrast (Iohexol) Removal.

Hsing-Yu Chen et al.

International journal of molecular sciences, 24(13) (2023-07-14)

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Maotao Du et al.

Annals of translational medicine, 9(23), 1722-1722 (2022-01-25)

Aloe-emodin is reported as a potential cancer therapeutic agent due to its inhibition of the proliferation, migration, and invasion of cancer cells. This study aimed to confirm the effects of aloe-emodin on the progression of melanoma and identify the underlying

DFMO inhibition of neuroblastoma tumorigenesis.

Divya Gandra et al.

Cancer medicine, 13(9), e7207-e7207 (2024-04-30)

Most high-risk neuroblastoma patients who relapse succumb to disease despite the existing therapy. We recently reported increased event-free and overall survival in neuroblastoma patients receiving difluoromethylornithine (DFMO) during maintenance therapy. The effect of DFMO on cellular processes associated with neuroblastoma

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抗细胞周期素D抗体

from rabbit, purified by affinity chromatography

选择尺寸

关于此项目

主要文件

属性

产品名称

antibody form

antibody product type

biological source

conjugate

clone

purified by

species reactivity

species reactivity (predicted by homology)

technique(s)

NCBI accession no.

UniProt accession no.

shipped in

target post-translational modification

Quality Level

Gene Information

相关类别

说明

Analysis Note

Application

Biochem/physiol Actions

Disclaimer

General description

Immunogen

Other Notes

Physical form

Preparation Note

安全信息

存储类别

wgk

flash_point_f

flash_point_c

文件

分析证书(COA)

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