ABF29
抗-NLRP6（NALP6）抗体
from rabbit, purified by affinity chromatography
别名:
NACHT, PYRIN-containing APAF1-like protein 5, LRR and PYD domains-containing protein 6
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
immunohistochemistry
western blot
western blot
Species reactivity:
rat, human
Citations:
4
Technique(s):
immunohistochemistry: suitable (paraffin)
western blot: suitable
western blot: suitable
Uniprot accession no.:
产品名称
抗-NLRP6（NALP6）抗体, from rabbit, purified by affinity chromatography
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
rat, human
species reactivity (predicted by homology)
rhesus macaque (based on 100% sequence homology)
technique(s)
immunohistochemistry: suitable (paraffin)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... NLRP6(171389)
Analysis Note
对照
大鼠嗜碱细胞性白血病（RBL）细胞裂解物
大鼠嗜碱细胞性白血病（RBL）细胞裂解物
通过蛋白质印迹在大鼠嗜碱细胞性白血病（RBL）细胞裂解物中进行了评估。
蛋白质印迹分析：1µg/mL的该抗体在10µg大鼠嗜碱细胞性白血病（RBL）细胞裂解物中检测到NLRP6（NALP6）。
蛋白质印迹分析：1µg/mL的该抗体在10µg大鼠嗜碱细胞性白血病（RBL）细胞裂解物中检测到NLRP6（NALP6）。
Application
免疫组化分析：代表性批次的1：1,000稀释液在人肾近端和远端小管的上皮组织以及人骨髓组织中检测到NLRP6（NALP6）。
抗NLRP6（NALP6）抗体可检测NLRP6水平 & 已发表&并经过验证可用于WB、IH(P)。
Biochem/physiol Actions
其他同源性：小鼠（93% 序列同源性）。
该抗体识别NLRP6（NALP6）的NACHT结构域。
General description
NRLP6（NALP6）（也称为含热蛋白的Apaf-1样蛋白5或PYPAF5）属于蛋白质家族，在凋亡和炎症信号传导中起关键作用。其表达高度限于粒细胞和T细胞。NALP6与ASC的共表达导致胱天蛋白酶-1依赖性细胞因子加工的协同激活，随后的NF-kB激活以及PYPAF5在细胞质中的点状结构的下游募集。NALP6/PYPAF5基因座中的重叠基因编码两个V2型加压素同种受体：血管紧张素-加压素受体（AVR）和非AVR。
观察值〜99 kDa
Immunogen
对应于人NLRP6（NALP6）的NACHT结构域的线性肽。
表位：NACHT结构域
Other Notes
浓度：请参考批次特异性浓缩物的分析证书。
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Pierre-Gregoire Coulon et al.
Frontiers in immunology, 10, 1631-1631 (2019-08-02)
The crosstalk between the host's inflammasome system and the invading virulent/less-virulent viruses determines the outcome of the ensuing inflammatory response. An appropriate activation of inflammasomes triggers antiviral inflammatory responses that clear the virus and heal the inflamed tissue. However, an
Abdallah Mound et al.
PloS one, 18(1), e0279028-e0279028 (2023-01-21)
Nod-Like Receptor Pyrin domain-containing protein 6 (NLRP6), a member of the Nucleotide-oligomerization domain-Like Receptor (NLR) family of proteins, assembles together with the ASC protein to form an inflammasome upon stimulation by bacterial lipoteichoic acid and double-stranded DNA. Besides its expression
David Furman et al.
Nature medicine, 23(2), 174-184 (2017-01-17)
Low-grade, chronic inflammation has been associated with many diseases of aging, but the mechanisms responsible for producing this inflammation remain unclear. Inflammasomes can drive chronic inflammation in the context of an infectious disease or cellular stress, and they trigger the
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