ABN411
抗水通道蛋白-4抗体
from rabbit, purified by affinity chromatography
别名:
Aquaporin-4, AQP-4, Mercurial-insensitive water channel, MIWC, WCH4
产品名称
抗水通道蛋白-4抗体, from rabbit, purified by affinity chromatography
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
mouse, rat, human
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... AQP4(361)
mouse ... Aqp4(11829)
rat ... Aqp4(25293)
Immunogen
表位：细胞质结构域
KLH偶联的线性肽，对应于大鼠水通道蛋白-4的胞质域。
Other Notes
浓度：请参考批次特异性浓缩物的分析证书。
Physical form
亲和纯化
在含 0.1 M Tris-甘氨酸（pH 7.4），150 mM NaCl 和 0.05％ 叠氮化钠的缓冲液中的纯化的兔多克隆抗体。
Analysis Note
对照
人脑组织裂解液
人脑组织裂解液
通过蛋白质印迹对人脑组织裂解物进行了评估。
蛋白质印迹分析：1.0 µg/mL的该抗体可在10 µg人脑组织裂解物中检测到水通道蛋白-4。
蛋白质印迹分析：1.0 µg/mL的该抗体可在10 µg人脑组织裂解物中检测到水通道蛋白-4。
Application
抗水通道蛋白-4是靶向水通道蛋白-4蛋白的抗体，经验证可用于WB。
研究子类别
发育神经科学
发育神经科学
研究类别
神经科学
神经科学
Biochem/physiol Actions
该抗体可识别水通道蛋白-4的胞质域。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
水通道蛋白-4（AQP-4）又称汞不敏感水通道。AQP-4一种渗透压感受器，可调节体内水平衡并介导中枢神经系统内的水流。它主要在成熟的大脑中表达，但也在眼睛，肾脏，肠和肺中表达。AQP-4是一种多通道膜蛋白，与MLC1，TRPV4，HEPACAM和ATP1B1一起作为复合物的一部分。
观察值〜32 kDa
Preparation Note
自收到之日起，在 2-8°C 条件下可稳定保存1年
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Maria Uldall et al.
Neuroscience letters, 645, 33-39 (2017-02-22)
Acetazolamide is one of the most widely used drugs for lowering intracranial pressure (ICP) and is believed to reduce cerebrospinal fluid (CSF) secretion via its action on the choroid plexus (CP). In the CP the main driving force for CSF
Ye Liu et al.
Journal of neuroinflammation, 20(1), 309-309 (2023-12-22)
Neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory autoimmune disease of the central nervous system that involves B-cell receptor signaling as well as astrocyte-microglia interaction, which both contribute to evolution of NMOSD lesions. Through transcriptomic and flow cytometry analyses, we
Yupeng Wang et al.
Frontiers in immunology, 14, 1144532-1144532 (2023-04-15)
Aquaporin-4 immunoglobulin G (AQP4-IgG)-induced astrocytes injury is a key mechanism in the pathogenesis of neuromyelitis spectrum disorder (NMOSD), and although CCL2 is involved, its specific role has not been reported. We aimed to further investigate the role and potential mechanisms
Jacqueline A Hubbard et al.
ASN neuro, 9(1), 1759091416687846-1759091416687846 (2017-01-13)
Maintenance of glutamate and water homeostasis in the brain is crucial to healthy brain activity. Astrocytic glutamate transporter-1 (GLT1) and aquaporin-4 (AQP4) are the main regulators of extracellular glutamate and osmolarity, respectively. Several studies have reported colocalization of GLT1 and
Benjamin J Andreone et al.
Neuron, 94(3), 581-594 (2017-04-19)
The blood-brain barrier (BBB) provides a constant homeostatic brain environment that is essential for proper neural function. An unusually low rate of vesicular transport (transcytosis) has been identified as one of the two unique properties of CNS endothelial cells, relative
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