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Merck
CN

ABN899

抗-寡糖-2 抗体

from rabbit, purified by affinity chromatography

别名:

Oligodendrocyte transcription factor 2, bHLHe19, Olg-2, Oligo2, RACK17, RK17

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关于此项目

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
immunocytochemistry
immunohistochemistry
immunoprecipitation (IP)
western blot
Species reactivity:
mouse, rat, human
Citations:
5
Technique(s):
immunocytochemistry: suitable
immunohistochemistry: suitable (paraffin)
immunoprecipitation (IP): suitable
western blot: suitable
Uniprot accession no.:
Q9EQW6

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产品名称

抗-寡糖-2 抗体, from rabbit, purified by affinity chromatography

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

mouse, rat, human

technique(s)

immunocytochemistry: suitable
immunohistochemistry: suitable (paraffin)
immunoprecipitation (IP): suitable
western blot: suitable

NCBI accession no.

NP_058663

UniProt accession no.

Q9EQW6

shipped in

wet ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... OLIG2(10215)

相关类别

Analysis Note

通过蛋白质印迹在小鼠脑组织裂解液中进行了评估。

蛋白质印迹分析：1.0 µg/mL的该抗体可在10 µg小鼠脑组织裂解物中检测到Olig-2。

Application

免疫沉淀分析：10 µg代表性批次免疫沉淀500 µg小鼠脑组织裂解物中的Olig-2。
免疫组化分析：代表性批次的1：500稀释液在大鼠后脑组织切片中检测到Olig-2。
免疫细胞化学分析：代表性批次的1：500稀释液在PC12细胞中检测到Olig-2。
抗Olig-2抗体是针对Olig-2的抗体，用于蛋白质印迹，免疫沉淀，免疫细胞化学，免疫组化（石蜡）。

General description

少突胶质细胞转录因子2（UniProt Q9EQW6；也称为bHLHe19，Olg-2，Oligo2，RACK17，RK17）由鼠物种中的Olig2（也称为Bhlhb1）基因（基因ID 50913）编码。Olig2是在脊髓心室区域表达的碱性螺旋-环-螺旋（bHLH）转录因子，在胚胎发生过程中介导运动神经元和少突胶质细胞的顺序生成。Olig2在早期时间点还充当pMN祖细胞中的抗神经源性因子，以维持循环祖细胞池。Olig2的抗神经源性也在肿瘤发生中起作用，特别是在脑肿瘤和白血病中。由于其在胶质母细胞瘤和其他弥漫性神经胶质瘤中的表达，Olig2是这些脑肿瘤的有用诊断标志物。
观察值〜37 kDa。计算值为32.40 kDa。

Immunogen

KLH偶联线性肽，对应于小鼠Olig-2的N末端区域中的序列。

Other Notes

替代品：AB15328
浓度：请参考特定批次的数据表。

Physical form

PBS和0.1 %叠氮化钠中的纯化的兔多克隆抗体。

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存储类别

10 - Combustible liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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Shiji Deng et al.
Advanced science (Weinheim, Baden-Wurttemberg, Germany), 10(5), e2202976-e2202976 (2022-12-20)
White matter injury (WMI), which reflects myelin loss, contributes to cognitive decline or dementia caused by cerebral vascular diseases. However, because pharmacological agents specifically for WMI are lacking, novel therapeutic strategies need to be explored. It is recently found that
Kelsie Mozzoni LaBarbera et al.
Journal of neuroscience methods, 358, 109180-109180 (2021-04-10)
Mature primary neuronal cultures are an important model of the nervous system, but limited scalability has been a major challenge in their use for drug discovery of neurodegenerative diseases. This work describes a method for improving scalability through the use
Luiza Stanaszek et al.
Antioxidants (Basel, Switzerland), 11(6) (2022-06-25)
Amyotrophic lateral sclerosis (ALS) is a progressive, fatal disease with no effective therapy. The neurodegenerative character of ALS was an appealing target for stem cell-based regenerative approaches. Different types of stem cells have been transplanted in both preclinical and clinical
Colleen S Limegrover et al.
Journal of neuroscience research, 99(4), 1161-1176 (2021-01-23)
α-Synuclein oligomers are thought to have a pivotal role in sporadic and familial Parkinson's disease (PD) and related α-synucleinopathies, causing dysregulation of protein trafficking, autophagy/lysosomal function, and protein clearance, as well as synaptic function impairment underlying motor and cognitive symptoms
Luiza Stanaszek et al.
Cells, 10(11) (2021-11-28)
Dysfunction of glia contributes to the deterioration of the central nervous system in a wide array of neurological disorders, thus global replacement of glia is very attractive. Human glial-restricted precursors (hGRPs) transplanted intraventricularly into neonatal mice extensively migrated and rescued

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