ABN99

抗磷酸NR1（Ser897）抗体

Name: 抗磷酸NR1（Ser897）抗体
Brand: MM

from rabbit, purified by affinity chromatography

别名:

glutamate receptor, ionotropic, N-methyl D-aspartate 1, N-methyl-D-aspartate receptor subunit NR1, glutamate [NMDA] receptor subunit zeta 1, N-methyl-D-aspartate receptor channel, subunit zeta-1, glutamate [NMDA] receptor subunit zeta-1

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关于此项目

UNSPSC Code:

12352203

NACRES:

NA.41

eCl@ss:

32160702

Clone:

polyclonal

Species reactivity:

rat

Application:

immunohistochemistry
immunoprecipitation (IP)
western blot

Technique(s):

immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

Citations:

Uniprot accession no.:

Q05586

主要文件

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产品名称

抗磷酸NR1（Ser897）抗体, from rabbit, purified by affinity chromatography

biological source

rabbit

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

rat

species reactivity (predicted by homology)

mouse (based on 100% sequence homology), human (based on 100% sequence homology)

technique(s)

immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

UniProt accession no.

Q05586

shipped in

wet ice

target post-translational modification

phosphorylation (pSer897)

Quality Level

100

Gene Information

human ... GRIN1(2902)
mouse ... Grin1(14810)
rat ... Grin1(24408)

Analysis Note

对照
大鼠脑微粒体组织裂解物

通过蛋白质印迹在大鼠脑微粒体组织裂解物中进行了评估。
蛋白质印迹分析：1 µg/mL该抗体在10 µg大鼠脑微粒体组织裂解物中检测到NR1。

Application

免疫组化分析：先前批次的1：50稀释液在正常大鼠海马中检测到NR1。
免疫沉淀分析：10 µg先前批次免疫沉淀来自大鼠脑微粒体RIPA裂解物的NR1。
蛋白质印迹分析：2 µg/mL先前批次在λ磷酸酶未处理和处理的大鼠脑微粒体组织裂解物中检测到NR1。

研究子类别
信号传导神经科学

研究类别
神经科学

该抗磷酸NR1（Ser897）抗体经验证可用于WB、IP、IH检测磷酸NR1（Ser897）。

Biochem/physiol Actions

在Ser897磷酸化后该抗体可识别NR1。

Disclaimer

除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

General description

NR1（NMDA1或NMDAR1，也称为GRIN1）与NR2亚基一起形成构成NMDA受体的异二聚体。NMDA受体（NMDAR）的特征是谷氨酸的离子通道型受体。顾名思义，（NMDA（N-甲基D-门冬氨酸）是该受体的激动剂。NMDA受体的一个独特的特征是，基于其对镁的敏感性，它既具有配体门控性也具有电压依赖性。活化的NMDA受体导致打开对阳离子非选择性的离子通道。结果是Na+和少量Ca2+离子流入细胞，K+流出细胞。NMDAR的钙通量与突触可塑性有关，突触可塑性是细胞中学习和记忆的一种机制。

~120 kDa

Immunogen

当在Ser897磷酸化时，KLH偶联线性肽对应于大鼠NR1。

表位：磷酸化的Ser897

Other Notes

替代品：06-641

Physical form

亲和纯化

在含 0.1 M Tris-甘氨酸（pH 7.4），150 mM NaCl 和 0.05％叠氮化钠的缓冲液中的纯化的兔多克隆抗体。

Preparation Note

自收到之日起，在 2-8°C 条件下可稳定保存1年

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存储类别

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

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HIV-1 gp120Bal down-Regulates Phosphorylated NMDA Receptor Subunit 1 in Cortical Neurons via Activation of Glutamate and Chemokine Receptors.

Wenjuan Ru et al.

Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology, 11(1), 182-191 (2015-11-20)

HIV-1 envelope glycoprotein gp120 (gp120) is a major virulence protein implicated in the pathogenesis of HIV-associated neurocognitive disorders (HAND). Although gp120 has been suggested to cause synaptic and neuronal injuries by disrupting NMDA receptor (NMDAR) function, the underlying mechanism is

Regular physical activity prevents development of chronic pain and activation of central neurons.

Sluka, KA; O'Donnell, JM; Danielson, J; Rasmussen, LA

Journal of Applied Physiology (1985)

Short-duration physical activity prevents the development of activity-induced hyperalgesia through opioid and serotoninergic mechanisms.

Lucas V Lima et al.

Pain, 158(9), 1697-1710 (2017-06-18)

Regular physical activity prevents the development of chronic muscle pain through the modulation of central mechanisms that involve rostral ventromedial medulla (RVM). We tested if pharmacological blockade or genetic deletion of mu-opioid receptors in physically active mice modulates excitatory and

Effect of dexmedetomidine on the development of mechanical allodynia and central sensitization in chronic post-ischemia pain rats.

Jinseok Yeo et al.

Journal of pain research, 11, 3025-3030 (2018-12-21)

Complex regional pain syndrome type 1 (CRPS I) is an intractable neuropathic pain syndrome. Chronic post-ischemia pain (CPIP) model is an animal model of CRPS I which is produced by ischemia-reperfusion (IR) injury of the hind limb. Dexmedetomidine (DEX) is

Effects of Glutathione on Mechanical Allodynia and Central Sensitization in Chronic Postischemic Pain Rats.

Jinseok Yeo et al.

Pain research & management, 2017, 7394626-7394626 (2017-12-07)

The chronic postischemia pain (CPIP) model is an animal model using ischemia/reperfusion injury that mimics the symptoms of complex regional pain syndrome type I. Glutathione (GSH) prevents ischemia/reperfusion injury by scavenging free radicals. We conducted this study to investigate the

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抗磷酸NR1（Ser897）抗体

from rabbit, purified by affinity chromatography

选择尺寸

关于此项目

主要文件

属性

产品名称

biological source

antibody form

antibody product type

clone

purified by

species reactivity

species reactivity (predicted by homology)

technique(s)

UniProt accession no.

shipped in

target post-translational modification

Quality Level

Gene Information

相关类别

说明

Analysis Note

Application

Biochem/physiol Actions

Disclaimer

General description

Immunogen

Other Notes

Physical form

Preparation Note

安全信息

存储类别

wgk

flash_point_f

flash_point_c

文件

分析证书(COA)

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