ABS30
抗磺酸修饰半胱氨酸（2-硫二甲酮特异性 Ig）抗体
serum, from rabbit
别名:
Sulfenic Acid Modified Cysteine (2-Thiodimedone-Specific Ig)
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Clone:
polyclonal
Species reactivity:
human, mouse, rat
Application:
WB
Citations:
9
biological source
rabbit
Quality Level
antibody form
serum
antibody product type
primary antibodies
clone
polyclonal
species reactivity
human, mouse, rat
species reactivity (predicted by homology)
all
technique(s)
western blot: suitable
isotype
IgG
shipped in
wet ice
target post-translational modification
unmodified
General description
蛋白质亚磺酸的形成是可逆的翻译后修饰，可用于监测目标蛋白质内反应性半胱氨酸上的蛋白质氧化。这可以用二甲酮衍生的蛋白质亚磺酸检测到。
预计会有泛抗体涂片。
Immunogen
对应于次磺酸修饰蛋白的线性肽。
Application
免疫荧光分析： 先前批次已被独立实验室用于IF。(Seo, YH, et al. (2009).PNAS.106(38): 16163-16168.)
抗-磺酸修饰半胱氨酸（2-Thiodimedone-Specific Ig）抗体可检测磺酸修饰半胱氨酸水平，&经发表 & 验证可用于 WB。
Biochem/physiol Actions
该抗体识别亚磺酸修饰的蛋白质。针对所有物种的泛修饰。
Analysis Note
已通过蛋白质印迹法在大鼠心室肌细胞裂解液中进行了评估。
蛋白质印迹分析：该抗体（稀释度 01:1,000 ）在 10 µg 大鼠心室肌细胞裂解物中检测到亚磺酸修饰的蛋白。
蛋白质印迹分析：该抗体（稀释度 01:1,000 ）在 10 µg 大鼠心室肌细胞裂解物中检测到亚磺酸修饰的蛋白。
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存储类别
10 - Combustible liquids
wgk
WGK 1
Ester Zito et al.
Molecular cell, 48(1), 39-51 (2012-09-18)
Endoplasmic reticulum (ER) thiol oxidases initiate a disulfide relay to oxidatively fold secreted proteins. We found that combined loss-of-function mutations in genes encoding the ER thiol oxidases ERO1α, ERO1β, and PRDX4 compromised the extracellular matrix in mice and interfered with
Nannan Zhou et al.
The Journal of clinical investigation, 133(24) (2023-12-15)
Elevation of reactive oxygen species (ROS) levels is a general consequence of tumor cells' response to treatment and may cause tumor cell death. Mechanisms by which tumor cells clear fatal ROS, thereby rescuing redox balance and entering a chemoresistant state
Phillip A Wages
Current protocols in toxicology, 71, 17-17 (2017-02-02)
Protein sulfenylation is a post-translational modification that is linked to many cell signaling networks and specific protein functions, thus the detection of any sulfenylated protein after a toxicological exposure is of importance. Specifically, the detection of protein sulfenylation can provide
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| ABS30 | 04053252517587 |