产品名称
抗肌脂蛋白抗体, from rabbit, purified by affinity chromatography
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
purified by
affinity chromatography
species reactivity
rabbit
species reactivity (predicted by homology)
rat (based on 100% sequence homology), human (immunogen homology), mouse (based on 100% sequence homology)
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... SLN(6588)
Analysis Note
对照
兔股四头肌组织
兔股四头肌组织
通过蛋白质印迹法对兔股四头肌组织裂解物进行评估。
蛋白质印迹分析：1 µg/mL 的该抗体在兔股四头肌组织裂解液中检测到肌脂蛋白。
蛋白质印迹分析：1 µg/mL 的该抗体在兔股四头肌组织裂解液中检测到肌脂蛋白。
Application
使用经过验证可用于蛋白质印迹的抗肌脂蛋白抗体检测肌脂蛋白。
研究子类别
细胞骨架
细胞骨架
研究类别
细胞结构
细胞结构
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
肌磷脂 (SLN) 是一种多结构域蛋白，包含管腔结构域、细胞质结构域和跨膜结构域。它存在于心肌细胞的肌浆/内质网膜中，并参与维持心脏肌肉收缩性的钙稳态。肌脂蛋白通过调节肌（内）质网 Ca2+ ATP 酶 (SERCA2a) 来实现这些效果，SERCA2a 是一种钙转运蛋白，可主动将钙从细胞质泵入肌浆网，从而导致心肌松弛。肌磷脂还可能与受磷蛋白相互作用，并可能导致心力衰竭。
观测分子量〜6 kDa。在某些组织裂解物中，在〜13 kDa处可能观察到未表征的条带。
Immunogen
KLH偶联的线性肽，对应于人肌脂蛋白的C端。
Other Notes
浓度：请参考批次特异性浓缩物的检验报告。
Physical form
亲和纯化
纯化的兔多克隆血清，溶于含有0.1 M Tris-甘氨酸（pH 7.4）、150 mM NaCl和0.05％叠氮化钠的缓冲液中。
Preparation Note
自收到之日起，在2-8°C条件下可稳定保存1年。
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Diane M Sepa-Kishi et al.
Scientific reports, 7(1), 15430-15430 (2017-11-15)
This study investigated fiber type-specific metabolic responses and the molecular mechanisms that regulate glucose and fat metabolism in oxidative and glycolytic muscles upon cold acclimation. Male Wistar rats were exposed to cold (4 °C) for 7 days, and then glycogen synthesis
John Butler et al.
Archives of biochemistry and biophysics, 569, 26-31 (2015-02-11)
Studies in sarcolipin knockout mice have led to the suggestion that skeletal muscle sarcolipin plays a role in thermogenesis. The mechanism proposed is uncoupling of the sarcoplasmic reticulum calcium pump. However, in other work sarcolipin was not detected in mouse
Victoria L Wyckelsma et al.
American journal of human genetics, 108(3), 446-457 (2021-02-19)
The protein α-actinin-3 expressed in fast-twitch skeletal muscle fiber is absent in 1.5 billion people worldwide due to homozygosity for a nonsense polymorphism in ACTN3 (R577X). The prevalence of the 577X allele increased as modern humans moved to colder climates
Joseph M Autry et al.
Veterinary sciences, 7(4) (2020-11-19)
Ca2+ regulation in equine muscle is important for horse performance, yet little is known about this species-specific regulation. We reported recently that horse encode unique gene and protein sequences for the sarcoplasmic reticulum (SR) Ca2+-transporting ATPase (SERCA) and the regulatory
David Morales-Alamo et al.
Scandinavian journal of medicine & science in sports, 30(3), 408-420 (2019-11-02)
Sarcolipin (SLN) is a SERCA uncoupling protein associated with exercise performance and lower adiposity in mice. To determine SLN protein expression in human skeletal muscle and its relationship with adiposity, resting energy expenditure (REE), and performance, SLN was assessed by
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