AM80
抗-PAR（Ab-1）小鼠mAb(10H)
liquid, ≥95% (SDS-PAGE), clone 10H
别名:
抗多腺苷二磷酸核糖
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Clone:
10H, monoclonal
Species reactivity:
human, Drosophila, rat, mouse
Application:
—
Citations:
31
biological source
mouse
antibody form
purified antibody
antibody product type
primary antibodies
clone
10H, monoclonal
assay
≥95% (SDS-PAGE)
form
liquid
contains
≤0.1% sodium azide as preservative
species reactivity
human, Drosophila, rat, mouse
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze, avoid repeated freeze/thaw cycles
dilution
(Immunoblotting (2.5 µg/mL)
Immunocytochemistry (5-20 µg/mL))
isotype
IgG3
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
General description
蛋白 A 纯化的小鼠单克隆抗体。识别聚ADP-核糖。
识别依托泊苷处理的HL-60细胞中的聚（ADP）-核糖（PAR）。
该抗PAR（Ab-1）小鼠mAb（10H）经验证可用于免疫印迹、免疫细胞化学检测PAR（Ab-1）。
Immunogen
牛
纯化的聚（ADP-核糖）
Application
免疫印迹（2.5 µg/ml）
免疫细胞化学（5-20 µg/ml）
免疫细胞化学（5-20 µg/ml）
Packaging
请参考特定浓度批号的标签。
Physical form
在100 mM NaCl，50 mM HEPES，1% BSA，pH 7.4中。
Preparation Note
初次融化后，等分并冷冻（-20°C）。
Analysis Note
阳性对照
依托泊苷处理的HL-60细胞
依托泊苷处理的HL-60细胞
阴性对照
正常小鼠IgG
正常小鼠IgG
Other Notes
Kawamitsu, H., et al. 1984.Biochemistry23, 3771.
用67 µM依托泊苷处理3.5 h可诱导HL-60细胞中的PAR。应滴定抗体，以在单个系统中获得最佳结果。
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
毒性：标准处理（A）
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存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Dominic I James et al.
F1000Research, 5, 736-736 (2016-10-16)
After a DNA damage signal multiple polymers of ADP ribose attached to poly(ADP) ribose (PAR) polymerases (PARPs) are broken down by the enzyme poly(ADP) ribose glycohydrolase (PARG). Inhibition of PARG leads to a failure of DNA repair and small molecule
Yuki Kurauchi et al.
Journal of neurochemistry, 116(3), 323-333 (2010-07-24)
Stimulation of retinoic acid receptors (RARs) protects midbrain dopaminergic neurons, presumably via up-regulation of brain-derived neurotrophic factor (BDNF) expression. The present study was focused on unexplored signaling mechanisms linking RAR stimulation to BDNF expression. Rat midbrain slice cultures treated with
J Wang et al.
Oncogene, 36(43), 5939-5947 (2017-06-27)
Understanding the mechanisms of platinum compound resistance, including cisplatin resistance, has important implications for improving cancer treatments. Previous studies identified a potential role for mitogen-activated protein kinase phosphatase-1 (MKP-1) in cisplatin resistance. This work focuses on the regulation of poly(ADP-ribose)
Gautier Stoll et al.
Oncoimmunology, 8(6), e1571389-e1571389 (2019-05-10)
The expression of two metabolic enzymes, i.e., aldehyde dehydrogenase 7 family, member A1 (ALDH7A1) and lipase C, hepatic type (LIPC) by malignant cells, has been measured by immunohistochemical methods in non-small cell lung carcinoma (NSCLC) biopsies, and has been attributed
Li-Li Zhuang et al.
PloS one, 8(10), e77304-e77304 (2013-11-10)
All-trans retinoic acid (ATRA) is an active metabolite of Vitamin A, it shows protective effects on asthma, including maintains airway epithelial integrity, inhibits asthma effector cells differentiation, modulates immune response, et al. However, the promoting effect of ATRA on Th2
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