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FCABS400F

Sigma-Aldrich

Milli-Mark® 抗-FcεRI抗体,γ 亚基-FITC

Milli-Mark®, from rabbit

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别名:
Fc fragment of IgE high affinity I receptor for gamma polypeptide, Fc-epsilon RI-gamma, FceRI gamma, IgE Fc receptor subunit gamma, Immunoglobulin E receptor, high affinity,gamma chain
eCl@ss:
32160702
NACRES:
NA.41

生物来源

rabbit

质量水平

偶联物

FITC conjugate

抗体形式

purified immunoglobulin

抗体产品类型

primary antibodies

克隆

polyclonal

种属反应性

mouse, human, rat

制造商/商品名称

Milli-Mark®

技术

flow cytometry: suitable

同位素/亚型

IgG

NCBI登记号

UniProt登记号

运输

wet ice

靶向翻译后修饰

unmodified

基因信息

human ... FCER1G(2207)

一般描述

I型过敏反应是通过IgE高亲和受体(FceRI)介导的。当呈递多价抗原时,单体IgE FceRI受体复合物的重新分布会导致肥大细胞和嗜碱性粒细胞脱粒,从而导致随后释放引起I型过敏反应的因子。FceRI受体是四聚体复合物,由a链,b链和二聚体g链组成。尽管a链主要参与IgE的结合,但信号通过g亚基转移,g亚基包含免疫受体酪氨酸激活基序(ITAM),对于通过Syk和Lyn酪氨酸激酶启动受体介导的信号转导至关重要。FceRI受体能够与IgE结合和脱离,为研究激酶偶联受体的性能提供了通用模型。

特异性

可识别并特异于FcεRI,γ-亚基。

免疫原

与Fc受体γ亚基的80-86氨基酸对应的合成肽。

应用

Milli-Mark 抗-FcεRI抗体,γ亚基-FITC是针对FcεRI的抗体,用于FC。
研究子类别
炎症 & 自身免疫机制
研究类别
炎症 & 免疫学

质量

通过流式细胞术对RBL细胞进行了评估

目标描述

计算值为10 kDa

外形

在含0.1%叠氮化钠和15 mg/mL BSA的PBS中与FITC偶联的纯化的兔多克隆IgG。
纯化的蛋白 A

储存及稳定性

自收到之日起,未稀释等分试样避光冷藏于 2-8°C,可保存6个月。

分析说明

对照
RBL细胞

其他说明

已证明非偶联抗体(目录编号06-727)对人和小鼠有效。
最佳工作稀释度必须由其它仪器的最终用户进行确定。

法律信息

MILLI-MARK is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

储存分类代码

12 - Non Combustible Liquids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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Cristina Capuano et al.
Frontiers in immunology, 9, 1031-1031 (2018-06-06)
Natural killer (NK) cells represent a pivotal player of innate anti-tumor immune responses. The impact of environmental factors in shaping the representativity of different NK cell subsets is increasingly appreciated. Human cytomegalovirus (HCMV) infection profoundly affects NK cell compartment, as
Marc Potempa et al.
Journal of immunology (Baltimore, Md. : 1950), 208(7), 1742-1754 (2022-03-25)
Although interactions between inhibitory Ly49 receptors and their self-MHC class I ligands in C57BL/6 mice are known to limit NK cell proliferation during mouse CMV (MCMV) infection, we created a 36-marker mass cytometry (CyTOF) panel to investigate how these inhibitory
Jingling Zhou et al.
Journal of immunology (Baltimore, Md. : 1950), 194(10), 4688-4697 (2015-04-10)
We previously demonstrated that NK cells from HIV-infected individuals have elevated expression of activation markers, spontaneously degranulate ex vivo, and decrease expression of a signal-transducing protein for NK-activating receptors, FcRγ. Importantly, these changes were maintained in virologically suppressed (VS) individuals
Ralf Grutza et al.
Journal of immunology (Baltimore, Md. : 1950), 204(11), 2910-2917 (2020-04-15)
Infection with the human CMV associates with phenotypic alterations in lymphocyte subsets. A highly reproducible finding in CMV-seropositive individuals is an expansion of NKG2Cpos NK cells. In this study, we analyzed if the altered NK cell compartment in CMV-seropositive human
Carmen Gómez-Escolar et al.
EMBO reports, 23(12), e55000-e55000 (2022-10-08)
Germinal centers (GC) are microstructures where B cells that have been activated by antigen can improve the affinity of their B cell receptors and differentiate into memory B cells (MBCs) or antibody-secreting plasma cells. Here, we have addressed the role

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