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Merck
CN

FCABS400F

Milli-Mark® 抗-FcεRI抗体，γ 亚基-FITC

Milli-Mark®, from rabbit

别名:

Fc fragment of IgE high affinity I receptor for gamma polypeptide, Fc-epsilon RI-gamma, FceRI gamma, IgE Fc receptor subunit gamma, Immunoglobulin E receptor, high affinity,gamma chain

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关于此项目

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
FITC conjugate
Clone:
polyclonal
Application:
flow cytometry
Species reactivity:
mouse, human, rat
Citations:
20
Technique(s):
flow cytometry: suitable
Uniprot accession no.:
P30273

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产品名称

Milli-Mark® 抗-FcεRI抗体，γ 亚基-FITC, Milli-Mark®, from rabbit

biological source

rabbit

conjugate

FITC conjugate

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

species reactivity

mouse, human, rat

manufacturer/tradename

Milli-Mark®

technique(s)

flow cytometry: suitable

isotype

IgG

NCBI accession no.

NP_004097

UniProt accession no.

P30273

shipped in

wet ice

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... FCER1G(2207)

相关类别

Analysis Note

对照
RBL细胞
通过流式细胞术对RBL细胞进行了评估

Application

Milli-Mark 抗-FcεRI抗体，γ亚基-FITC是针对FcεRI的抗体，用于FC。
研究子类别
炎症 & 自身免疫机制
研究类别
炎症 & 免疫学

Biochem/physiol Actions

可识别并特异于FcεRI，γ-亚基。

Disclaimer

除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

General description

I型过敏反应是通过IgE高亲和受体（FceRI）介导的。当呈递多价抗原时，单体IgE FceRI受体复合物的重新分布会导致肥大细胞和嗜碱性粒细胞脱粒，从而导致随后释放引起I型过敏反应的因子。FceRI受体是四聚体复合物，由a链，b链和二聚体g链组成。尽管a链主要参与IgE的结合，但信号通过g亚基转移，g亚基包含免疫受体酪氨酸激活基序（ITAM），对于通过Syk和Lyn酪氨酸激酶启动受体介导的信号转导至关重要。FceRI受体能够与IgE结合和脱离，为研究激酶偶联受体的性能提供了通用模型。
计算值为10 kDa

Immunogen

与Fc受体γ亚基的80-86氨基酸对应的合成肽。

Other Notes

已证明非偶联抗体（目录编号06-727）对人和小鼠有效。
最佳工作稀释度必须由其它仪器的最终用户进行确定。

Physical form

在含0.1％叠氮化钠和15 mg/mL BSA的PBS中与FITC偶联的纯化的兔多克隆IgG。
纯化的蛋白 A

Preparation Note

自收到之日起，未稀释等分试样避光冷藏于 2-8°C，可保存6个月。

Legal Information

MILLI-MARK is a registered trademark of Merck KGaA, Darmstadt, Germany

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存储类别

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

分析证书(COA)

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Spandan V Shah et al.
Cell reports, 25(10), 2766-2774 (2018-12-06)
Despite burgeoning evidence demonstrating the adaptive properties of natural killer (NK) cells, mechanistic data explaining these phenomena are lacking. Following antibody sensitization, NK cells lacking the Fc receptor (FcR) signaling chain (Δg) acquire adaptive features, including robust proliferation, multifunctionality, rapid
Marc Potempa et al.
Journal of immunology (Baltimore, Md. : 1950), 208(7), 1742-1754 (2022-03-25)
Although interactions between inhibitory Ly49 receptors and their self-MHC class I ligands in C57BL/6 mice are known to limit NK cell proliferation during mouse CMV (MCMV) infection, we created a 36-marker mass cytometry (CyTOF) panel to investigate how these inhibitory
Zeguang Wu et al.
Journal of immunology (Baltimore, Md. : 1950), 207(10), 2534-2544 (2021-10-10)
Human CMV (HCMV) is a ubiquitous pathogen that indelibly shapes the NK cell repertoire. Using transcriptomic, epigenomic, and proteomic approaches to evaluate peripheral blood NK cells from healthy human volunteers, we find that prior HCMV infection promotes NK cells with
James D Dahlvang et al.
Journal of immunology (Baltimore, Md. : 1950), 210(8), 1108-1122 (2023-03-08)
CMV infection alters NK cell phenotype and function toward a more memory-like immune state. These cells, termed adaptive NK cells, typically express CD57 and NKG2C but lack expression of the FcRγ-chain (gene: FCER1G, FcRγ), PLZF, and SYK. Functionally, adaptive NK
Cristina Capuano et al.
Frontiers in immunology, 9, 1031-1031 (2018-06-06)
Natural killer (NK) cells represent a pivotal player of innate anti-tumor immune responses. The impact of environmental factors in shaping the representativity of different NK cell subsets is increasingly appreciated. Human cytomegalovirus (HCMV) infection profoundly affects NK cell compartment, as
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