产品名称
抗整合素αVβ 6抗体（克隆E7P6，无叠氮化物）, clone E7P6, Chemicon®, from mouse
biological source
mouse
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
E7P6, monoclonal
species reactivity
human
manufacturer/tradename
Chemicon®
technique(s)
flow cytometry: suitable
immunocytochemistry: suitable
immunohistochemistry: suitable
isotype
IgG1
suitability
not suitable for activity/function inhibition
not suitable for immunohistochemistry (Paraffin)
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... ITGAV(3685)
Application
免疫组化（丙酮固定）：可有效用于人类组织，特别是评估受体上调的场合。该抗体不可使福尔马林固定或石蜡包埋的组织染色，可能无法检测在健康成年人上皮细胞中αvβ6的低水平基础表达。
免疫细胞化学：可有效用于F6、HT-29、H441细胞系（其它细胞系未测试）。
流式细胞术：可有效检测人和猴αvβ6
对于免疫沉淀或蛋白质印迹无效。
最佳工作稀释度必须由最终用户进行确定。
免疫细胞化学：可有效用于F6、HT-29、H441细胞系（其它细胞系未测试）。
流式细胞术：可有效检测人和猴αvβ6
对于免疫沉淀或蛋白质印迹无效。
最佳工作稀释度必须由最终用户进行确定。
研究子类别
整合素
整合素
研究类别
细胞结构
细胞结构
该抗整合素αVβ6 抗体（克隆E7P6，无叠氮化物）经验证可用于FC、IC、IH检测整合素αVβ6。
Biochem/physiol Actions
单克隆抗体MAB2074Z，通过以重组分泌性人avb6使Balb/c小鼠免疫生成，可用于流式细胞术，在免疫细胞化学法中特别有用。 该抗体对于人类组织的免疫组织化学法很有效，特别是在评估受体上调的场合。 该抗体不可使福尔马林固定或石蜡包埋的组织染色，可能无法检测在健康成年人上皮细胞中αvβ6的低水平基础表达。该抗体不识别αV亚基，也不与αVβ6以外的αV整合素发生反应。 由于该抗体对于蛋白质印迹无效，我们不知道该抗体识别的表位是位于αvβ6异源二聚体上还是仅位于β6亚基上。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
Immunogen
重组分泌性人αvβ6
Physical form
在PBS中的1 mg/mL无菌过滤液体，不含防腐剂。
形式：纯化
Preparation Note
以未稀释的等分试样保存于2-8°C下12个月。
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Christopher J Legge et al.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 48(9), 803-809 (2019-07-17)
Patients with oral squamous cell carcinoma currently experience a five-year survival rate of approximately 60% with conventional surgical, chemotherapy and radiotherapy treatments. Magnetic hyperthermia offers an alternative treatment method by utilising the heating properties of magnetic nanoparticles to produce thermal
Jiarong Wang et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 36(6), 2198-2216 (2015-08-19)
IL-1β creates persistent pulmonary inflammation accompanied by elevated transforming growth factor β (TGF-β levels and is associated with abnormal elastogenesis, which is observed in bronchopulmonary dysplasia (BPD). Although progress has been made in this field, the mechanisms underlying this process
Yingshe Zhao et al.
Cancer research, 67(12), 5821-5830 (2007-06-19)
In breast cancer bone metastasis, tumor cells stimulate osteoclast-mediated bone resorption, and bone-derived growth factors released from resorbed bone stimulate tumor growth. The alphavbeta3 integrin is an adhesion receptor expressed by breast cancer cells and osteoclasts. It is implicated in
Maria L Nystrom et al.
Cancer research, 66(22), 10833-10842 (2006-11-17)
Worldwide oral squamous cell carcinoma (OSCC) represents about 5.5% of all malignancies, with approximately 30,000 new cases each year in the United States. The integrin alpha(v)beta(6) and the enzyme cyclooxygenase-2 (COX-2) are implicated in OSCC progression and have been suggested
A peptide selected by biopanning identifies the integrin alphavbeta6 as a prognostic biomarker for nonsmall cell lung cancer.
Elayadi, AN; Samli, KN; Prudkin, L; Liu, YH; Bian, A; Xie, XJ; Wistuba, II; Roth et al.
Cancer Research null
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