MAB308
抗多巴胺β羟化酶抗体，克隆4F10.2
ascites fluid, clone 4F10.2, Chemicon®
别名:
DBH
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
4F10.2, monoclonal
Application:
immunofluorescence
immunohistochemistry (formalin-fixed, paraffin-embedded sections)
immunohistochemistry (formalin-fixed, paraffin-embedded sections)
Species reactivity:
rat, bovine, sheep
Citations:
122
Technique(s):
immunofluorescence: suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
Uniprot accession no.:
产品名称
抗多巴胺β羟化酶抗体，克隆4F10.2, ascites fluid, clone 4F10.2, Chemicon®
biological source
mouse
conjugate
unconjugated
antibody form
ascites fluid
antibody product type
primary antibodies
clone
4F10.2, monoclonal
species reactivity
rat, bovine, sheep
manufacturer/tradename
Chemicon®
technique(s)
immunofluorescence: suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
isotype
IgG1
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Quality Level
Gene Information
bovine ... Dbh(280758)
rat ... Dbh(25699)
Analysis Note
免疫组化（石蜡）：大鼠脊髓中的多巴胺β羟化酶（目录号MAB308）染色模式/形态。 用pH 6.0的柠檬酸盐预处理组织。使用带有HRP-DAB的IHC-SelectDetection将这批抗体稀释至1:300。 免疫反应主要在背根神经节（DRG）中表达。
使用柠檬酸盐缓冲液，pH值6.0进行最佳染色，抗原表位修复：大鼠脊髓
使用柠檬酸盐缓冲液，pH值6.0进行最佳染色，抗原表位修复：大鼠脊髓
Application
已发表抗多巴胺β羟化酶抗体（克隆4F10.2）可检测多巴胺β羟化酶&水平，&经验证可用于IH、IH（P）&IF。
间接免疫荧光：
将先前批次的1：300-1：500稀释液用于大鼠脑组织。
最佳工作稀释度必须由最终用户进行确定。
免疫组化（石蜡）：
先前批次的代表性图像。
使用柠檬酸盐缓冲液，pH值6.0进行最佳染色，表位修复：大鼠脊髓
将先前批次的1：300-1：500稀释液用于大鼠脑组织。
最佳工作稀释度必须由最终用户进行确定。
免疫组化（石蜡）：
先前批次的代表性图像。
使用柠檬酸盐缓冲液，pH值6.0进行最佳染色，表位修复：大鼠脊髓
Biochem/physiol Actions
多巴胺β羟化酶（DBH）。
General description
多巴胺β羟化酶（DBH）是编码DβH酶的结构基因座，是影响血浆DβH活性的主要数量性状基因座，其中一个单核苷酸多态性（SNP）占方差的50%。DBH处的突变似乎是造成DβH缺乏症的罕见综合征的原因。 它是参与膜结合小分子神经递质合成的唯一酶，使去甲肾上腺素和肾上腺素成为囊泡内合成的唯一递质。它在中枢和外周神经系统的去甲肾上腺素能神经末梢以及肾上腺髓质的嗜铬细胞中表达。
Immunogen
纯化牛DBH。
Other Notes
替代品：MAB394-250UG；MAB394-100UG；MAB394-25UG
浓度：请参考批次特异性浓缩物的分析证书。
Physical form
在含 0.1%叠氮化钠的液体中的腹水小鼠单克隆IgG1。
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
12 - Non Combustible Liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
The rate of fall of blood glucose determines the necessity of forebrain-projecting catecholaminergic neurons for male rat sympathoadrenal responses.
Jokiaho, AJ; Donovan, CM; Watts, AG
Diabetes null
Differential activation of chemically identified neurons in the caudal nucleus of the solitary tract in non-entrained rats after intake of satiating vs. non-satiating meals.
Kreisler, AD; Davis, EA; Rinaman, L
Physiology & Behavior null
Glucocorticoid enhancement of memory requires arousal-induced noradrenergic activation in the basolateral amygdala.
Roozendaal, B; Okuda, S; Van der Zee, EA; McGaugh, JL
Proceedings of the National Academy of Sciences of the USA null
Michael D Schwartz et al.
eNeuro, 3(2) (2016-03-30)
Hypocretin 1 and 2 (Hcrts; also known as orexin A and B), excitatory neuropeptides synthesized in cells located in the tuberal hypothalamus, play a central role in the control of arousal. Hcrt inputs to the locus coeruleus norepinephrine (LC NE)
Hermina Nedelescu et al.
Brain structure & function, 222(1), 317-339 (2016-04-09)
The vermis or "spinocerebellum" receives input from the spinal cord and motor cortex for controlling balance and locomotion, while the longitudinal hemisphere region or "cerebro-cerebellum" is interconnected with non-motor cortical regions, including the prefrontal cortex that underlies decision-making. Noradrenaline release
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