产品名称
抗CFT抗MMP-2抗体，a.a。468-483 hMMP2，克隆 42-5D11, clone 42-5D11, Chemicon®, from mouse
biological source
mouse
conjugate
unconjugated
antibody form
purified antibody
antibody product type
primary antibodies
clone
42-5D11, monoclonal
species reactivity
rat, bovine, human, rabbit, horse, mouse, pig
manufacturer/tradename
Chemicon®
technique(s)
ELISA: suitable
immunohistochemistry: suitable (paraffin)
western blot: suitable
isotype
IgG1κ
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... MMP2(4313)
Analysis Note
对照
肺，神经和各种软组织肿瘤
肺，神经和各种软组织肿瘤
Application
免疫印迹1-5μ g/mL
使用PLP固定对冷冻和石蜡包埋的组织进行免疫组化：1-5μ g/ml（尚未在传统福尔马林固定组织中检测）
ElA
使用PLP固定对冷冻和石蜡包埋的组织进行免疫组化：1-5μ g/ml（尚未在传统福尔马林固定组织中检测）
ElA
研究子类别
MMPs & TIMPs
MMPs & TIMPs
研究类别
细胞结构
细胞结构
该抗MMP-2抗体，a.a.468-483 hMMP2，克隆42-5D11经验证可用于ELISA、IH（P）、WB检测MMP-2。
Biochem/physiol Actions
与人MMP-2的前体和活性形式发生特异性反应。不与人MMP-1、-3、-9或-13发生交叉反应。也可与大鼠、小鼠和牛MMP2发生反应，未检测的其他物种。
Disclaimer
由Daiichi Fine Chemical Co., Ltd生产
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
72kda
基质金属蛋白酶（MMPs）是至少18种分泌的和膜结合的锌肽链内肽酶家族。总的来说，这些酶可以降解全部细胞外基质的成分，包括纤维状和非纤维状胶原，纤维连接蛋白，层粘连蛋白和基底膜糖蛋白。全部MMPs合成为酶原，其中大多数是作为酶原从细胞中分泌出来的。因此，这些酶原的激活是导致细胞外基质分解的关键步骤。MMPs被认为在伤口愈合、细胞凋亡、骨伸长、胚胎发育、子宫复旧、血管生成和组织重塑、多发性硬化、阿尔茨海默′病、恶性胶质瘤、狼疮、关节炎、牙周炎、肾小球肾炎、动脉粥样硬化、组织溃疡、癌症细胞侵袭和转移等疾病中起重要作用。
MMP2，也称为明胶酶A，是一种IV型胶原酶，可特异性裂解IV型胶原（基底膜的主要结构成分）。已经发现肿瘤细胞的转移潜能与该酶的活性相关。
MMP2，也称为明胶酶A，是一种IV型胶原酶，可特异性裂解IV型胶原（基底膜的主要结构成分）。已经发现肿瘤细胞的转移潜能与该酶的活性相关。
Immunogen
对应于人基质金属蛋白酶2（人MMP-2，明胶酶A）的氨基酸残基468-483（VTPRDKPMGPLLVATF）的合成寡肽。
表位：a.a.468-483 hMMP2
Other Notes
浓度：请参考批次特异性浓缩物的分析证书。
Physical form
形式：纯化
液体溶于0.1 M磷酸钠缓冲液，pH值7.0，含有2%无蛋白酶的牛血清白蛋白。
纯化的蛋白 A
Preparation Note
自发运之日起在-20°C可保存1年。等分以避免反复冻融。为了最大程度地回收产品，在融化后和取下盖子之前，将原始样品瓶进行离心。
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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