产品名称
抗MAP2抗体，克隆AP20，Alexa氟石™555偶联物, clone AP20, from mouse, ALEXA FLUOR™ 555
biological source
mouse
conjugate
ALEXA FLUOR™ 555
antibody form
affinity purified immunoglobulin
antibody product type
primary antibodies
clone
AP20, monoclonal
species reactivity
rat, Xenopus, bovine, chicken, human, quail, mouse
technique(s)
immunocytochemistry: suitable
isotype
IgG
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
chicken ... Map2(424001)
frog ... Map2(780043)
human ... MAP2(4133)
mouse ... Map2(17756), Map2(281294)
rat ... Map2(25595)
Analysis Note
通过免疫细胞化学在大鼠E18原代皮层细胞中进行评估。
免疫细胞化学分析：该抗体以1：100稀释度在大鼠E18原代皮层细胞中检测到MAP2。
免疫细胞化学分析：该抗体以1：100稀释度在大鼠E18原代皮层细胞中检测到MAP2。
Application
该抗MAP2抗体，克隆AP20，Alexa Fluor 555偶联物经验证可用于ICC中检测MAP2。
General description
微管相关蛋白2（MAP-2）是一种丰富的神经元细胞骨架蛋白，可与微管蛋白结合，稳定微管（Herzog and Weber, 1978），并且是神经元的极佳标记物。MAP-2对于神经元形态的发育和维持至关重要（Matus，1991）。已经在神经元中鉴定出MAP-2的三种主要亚型，即高分子量MAP2a和MAP2b，以及低分子量MAP2c（由MAP2基因的交替剪接产生）。（Chung et al.，1996）。低分子量亚型MAP2c在发育中的大脑中表达，并在大脑成熟过程中被下调，而高分子量MAP2b在发育中和成年大脑中均表达。MAP2a仅在大脑成熟后出现（Tucker，1990）。全部这些形式通过羧基末端附近的域与微管结合，该域包含31个氨基酸基序的三个或四个相似重复序列（Lewis et al.，1988）。MAP-2与MAP-4和tau蛋白一起属于与微管相关的热稳定蛋白家族。
观测值〜230 kDa。
Physical form
在含 0.1％ 叠氮化钠和 15 mg/mL BSA 的 PBS 中的Alexa Fluor™555偶联的纯化的小鼠单克隆 IgG。
Legal Information
ALEXA FLUOR is a trademark of Life Technologies
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存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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