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Merck
CN

MAB352

抗-5-羟色胺抗体,克隆YC5/45

culture supernatant, clone YC5/45, Chemicon®

别名:

5-HT

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关于此项目

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Clone:
YC5/45, monoclonal
Species reactivity:
mouse, human, rat, lizard, rabbit, pig
Application:
IHC
Citations:
55
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Quality Level

biological source

rat

antibody form

culture supernatant

antibody product type

primary antibodies

clone

YC5/45, monoclonal

species reactivity

mouse, human, rat, lizard, rabbit, pig

manufacturer/tradename

Chemicon®

technique(s)

immunohistochemistry: suitable

isotype

IgG

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... HTR1A(3350)

Immunogen

与BSA偶联的5-羟色胺。

Application

抗5-羟色胺抗体,克隆YC5/45是用于IH的抗5-羟色胺抗体。
甲醛固定组织的免疫组织化学为1:100-1:200。

最佳工作稀释度必须由最终用户进行确定。
研究子类别
神经递质&受体
研究类别
神经科学

Biochem/physiol Actions

识别5-羟色胺的甲醛结合物。未经多聚甲醛处理,在血凝试验中与多巴胺和色胺在液相中有交叉反应。显示与甲醛固定制备物中含儿茶酚胺的神经元无反应性。MAB352与神经元中的5-羟色胺反应,并识别固定组织切片中的5-羟色胺能位点。通过细胞凝集,与5-羟吲哚乙酸、GABA、去甲肾上腺素、5-羟色氨酸、肌肽或褪黑激素无交叉反应。

Physical form

冻干上清液,不含防腐剂。
未纯化

Preparation Note

冻干抗体可在2-8°C下保存长达3个月,长期保存应在-20°C下保存。用100 μL无菌DI水复溶。将未稀释的等分试样在-20°C下保存长达12个月。应避免反复冻融循环。

Analysis Note

对照
脑组织

Other Notes

浓度:关于批次特定浓度请参见检验报告。

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

除非我们的目录或产品随附的其他公司文件中另有说明,否则我们的产品预期仅用于研究用途,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或对人类或动物的任何类型的消费或应用。

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Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

存储类别

11 - Combustible Solids

wgk

WGK 2


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Alexander Drobyshevsky et al.
Journal of neurochemistry, 132(4), 394-402 (2014-11-26)
We hypothesized that a deficiency in the descending serotonergic input to spinal cord may underlie postnatal muscle hypertonia after global antenatal hypoxic-ischemic injury in a rabbit model of cerebral palsy. Neurotransmitter content was determined by HPLC in the spinal cord
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Nature communications, 7, 10388-10388 (2016-01-23)
The molecular mechanisms underlying the ability of axons to regenerate after injury remain poorly understood. Here we show that in Caenorhabditis elegans, axotomy induces ectopic expression of serotonin (5-HT) in axotomized non-serotonergic neurons via HIF-1, a hypoxia-inducible transcription factor, and
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Hypothalamic neurons expressing histamine and orexin/hypocretin (hcrt) are necessary for normal regulation of wakefulness. In Parkinson's disease, the loss of dopaminergic neurons is associated with elevated histamine levels and disrupted sleep/wake cycles, but the mechanism is not understood. To characterize

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