产品名称
抗-p16抗体，克隆D25, clone D25, Chemicon®, from mouse
biological source
mouse
conjugate
unconjugated
antibody form
purified antibody
antibody product type
primary antibodies
clone
D25, monoclonal
species reactivity
human
manufacturer/tradename
Chemicon®
technique(s)
immunohistochemistry: suitable
western blot: suitable
isotype
IgG1
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... CDKN2A(1029)
Analysis Note
对照
阳性对照：HeLa细胞
结肠癌
阳性对照：HeLa细胞
结肠癌
Application
免疫印迹
免疫组织化学
最佳工作稀释度必须由最终用户确定。
免疫组织化学
最佳工作稀释度必须由最终用户确定。
抗p16抗体（克隆D25）是用于检测p16（也称为INK4a、MTS1、CDK4IN、CDKN2）的小鼠单克隆抗体，&已在WB & IHC中进行了验证。
研究子类别
细胞周期、DNA复制&修复
细胞周期、DNA复制&修复
研究类别
表观遗传学&核功能
表观遗传学&核功能
Biochem/physiol Actions
p16*是一种主要的肿瘤抑制基因，已知在许多类型的人类癌症中都被删除或突变。 抗体MAB4133以其重组或天然形式特异性结合p16。 其也识别黑色素瘤和原位痣表达的p16。
Disclaimer
除非我们的目录或产品随附的其他公司文件中另有说明，否则我们的产品预期仅用于研究用途，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或对人类或动物的任何类型的消费或应用。
Immunogen
来自大肠杆菌的重组p16融合蛋白。
Other Notes
替代：04-239
浓度：关于批次特定浓度请参见检验报告。
Physical form
形式：纯化
磷酸盐缓冲液中的液体，含有叠氮化物作为防腐剂。
Preparation Note
以未稀释的等分试样在2-8°C下冷藏保存长达12个月。
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Matt Lechner et al.
Oral oncology, 83, 32-37 (2018-08-14)
p16INK4A (p16) is the most widely used clinical biomarker for Human Papillomavirus (HPV) in head and neck squamous cell cancer (HNSCC). HPV is a favourable prognostic marker in HNSCC and is used for patient stratification. While p16 is a relatively
C Grønhøj Larsen et al.
British journal of cancer, 110(6), 1587-1594 (2014-02-13)
A significant proportion of squamous cell carcinomas of the oropharynx (OP-SCC) are related to human papillomavirus (HPV) infection and p16 overexpression. This subgroup proves better prognosis and survival but no evidence exists on the correlation between HPV and p16 overexpression
Amelia B Thompson et al.
Journal of lower genital tract disease, 22(4), 340-347 (2018-09-01)
Anal cancer rates are increasing among HIV-infected persons. Although an efficacious human papillomavirus (HPV) vaccine is available, HPV vaccination rates remain low. Therefore, providers perform anal cancer screening, but there is no consensus on the optimal methods or timing of
Qi Song et al.
Nature communications, 13(1), 4167-4167 (2022-07-20)
Squamous cell carcinoma (SCC) and adenocarcinoma (AC) are two main histological subtypes of solid cancer; however, SCCs are derived from different organs with similar morphologies, and it is challenging to distinguish the origin of metastatic SCCs. Here we report a
Alhadi Almangush et al.
British journal of cancer, 117(6), 856-866 (2017-07-29)
Identifying informative prognostic biomarkers for oral tongue squamous cell carcinoma (OTSCC) is of great importance in order to better predict tumour behaviour and to guide treatment planning. Here, we summarise existing evidence regarding immunohistochemical prognostic biomarkers for OTSCC. A systematic
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