产品名称
抗-亨廷顿蛋白抗体，a.a.1-82, ascites fluid, clone 2B4, Chemicon®
biological source
mouse
antibody form
ascites fluid
antibody product type
primary antibodies
clone
2B4, monoclonal
species reactivity
human
manufacturer/tradename
Chemicon®
technique(s)
ELISA: suitable
immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable
isotype
IgG1
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... HTT(3064), SLC6A4(6532)
Analysis Note
对照
正常人大脑皮层裂解物，来自HD或野生型小鼠的小鼠大脑皮层样品
正常人大脑皮层裂解物，来自HD或野生型小鼠的小鼠大脑皮层样品
Application
抗-亨廷顿蛋白抗体，a.a.1-82是用于ELISA、IC、IH&WB的抗亨廷顿蛋白的抗体。
研究子类别
神经退行性疾病
神经退行性疾病
研究类别
神经科学
神经科学
蛋白质印迹：1:500-1:5,000
免疫细胞化学（1）: 1:500-1:5,000
免疫组织化学（1，2）: 1:500-1:5000
ELISA：1:500-1:5,000
最佳工作稀释度必须由最终用户确定。
免疫细胞化学（1）: 1:500-1:5,000
免疫组织化学（1，2）: 1:500-1:5000
ELISA：1:500-1:5,000
最佳工作稀释度必须由最终用户确定。
Biochem/physiol Actions
与亨廷顿蛋白（氨基酸1-82）反应。该抗体可识别野生型和突变型亨廷顿蛋白。
Disclaimer
除非我们的目录或产品随附的其他公司文件中另有说明，否则我们的产品预期仅用于研究用途，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或对人类或动物的任何类型的消费或应用。
General description
348 kDa
Immunogen
表位：a.a.1-82
重组人亨廷顿蛋白，氨基酸1-82。
Other Notes
浓度：关于批次特定浓度请参见检验报告。
Physical form
不含防腐剂的腹水。
未纯化
Preparation Note
自收到之日起在-20°C可稳定保存1年。分装保存以避免反复冻融。为了最大程度地回收产品，需在融化后和取下盖子之前将原始样品管进行离心。
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Gennady Ermak et al.
The Journal of biological chemistry, 284(18), 11845-11853 (2009-03-10)
Our work suggests an important new link between the RCAN1 gene and Huntington disease. Huntington disease is caused by expansion of glutamine repeats in the huntingtin protein. How the huntingtin protein with expanded polyglutamines (mutant huntingtin) causes the disease is
Jack C Reidling et al.
Stem cell reports, 10(1), 58-72 (2017-12-14)
Huntington's disease (HD) is an inherited neurodegenerative disorder with no disease-modifying treatment. Expansion of the glutamine-encoding repeat in the Huntingtin (HTT) gene causes broad effects that are a challenge for single treatment strategies. Strategies based on human stem cells offer
Phosphorylation of mutant huntingtin at serine 116 modulates neuronal toxicity.
Watkin, EE; Arbez, N; Waldron-Roby, E; O'Meally, R; Ratovitski, T; Cole, RN; Ross, CA
Testing null
Sean M DeGuire et al.
The Journal of biological chemistry, 293(48), 18540-18558 (2018-09-07)
Huntington's disease is a fatal neurodegenerative disorder resulting from a CAG repeat expansion in the first exon of the gene encoding the Huntingtin protein (Htt). Phosphorylation of this protein region (Httex1) has been shown to play important roles in regulating
Sophie Vieweg et al.
The Journal of biological chemistry, 291(23), 12074-12086 (2016-03-24)
The first exon of the Huntingtin protein (Httex1) is one of the most actively studied Htt fragments because its overexpression in R6/2 transgenic mice has been shown to recapitulate several key features of Huntington disease. However, the majority of biophysical
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