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Merck
CN

MABC196

抗-几丁质酶-3样蛋白1(YKL-40)抗体,克隆mAY

clone mAY, from mouse

别名:

Chitinase-3-like protein 1, 39 kDa synovial protein, Cartilage glycoprotein 39, CGP-39, GP-39, hCGP-39, YKL-40

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关于此项目

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
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产品名称

抗-几丁质酶-3样蛋白1(YKL-40)抗体,克隆mAY, clone mAY, from mouse

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

mAY, monoclonal

species reactivity

human

technique(s)

activity assay: suitable
immunohistochemistry: suitable
western blot: suitable

isotype

IgG1κ

NCBI accession no.

UniProt accession no.

shipped in

dry ice

target post-translational modification

unmodified

Quality Level

Gene Information

human ... CHI3L1(1116)

Analysis Note

对照
MG-63条件培养基
通过蛋白质印迹法在MG-63条件培养基中进行评估。

蛋白质印迹分析:0.5 µg/mL该抗体在10 µg MG-63条件培养基中检测到几丁质酶-3样蛋白1(YKL-40)(该蛋白阻断肿瘤血管生成管的形成和进展(Faibish,M.,et al.(2011).Mol Cancer Ther.10(5):742-751.))。

Application

免疫细胞化学分析:一个来自独立实验室的代表性批次在U87细胞中检测到几丁质酶-3样蛋白1(YKL-40)(该蛋白阻断肿瘤血管生成管的形成和进展(Faibish,M.,et al.(2011).Mol Cancer Ther.10(5):742-751.))。

活性测定分析:一个来自独立实验室的代表性批次在中和测定中中和了几丁质酶-3样蛋白1(Faibish,M.,et al.(2011).Mol Cancer Ther.10(5):742-751.)。
研究子类别
发育信号传导
研究类别
细胞结构
该抗几丁质酶-3样蛋白1(YKL-40)抗体克隆经验证可用于检测几丁质酶-3样蛋白1(YKL-40)的蛋白质印迹、IHC、活性测定。

Disclaimer

除非我们的目录或产品随附的其他公司文件中另有说明,否则我们的产品预期仅用于研究用途,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或对人类或动物的任何类型的消费或应用。

General description

YKL-40(几丁质酶-3样蛋白1;人软骨糖蛋白39)是一种分泌的糖蛋白,属于糖基水解酶18(GH18)家族。主要存在于软骨细胞、活化的巨噬细胞和肝细胞中。YKL-40的确切生物学功能仍然未知。但是,最近的研究表明,YKL-40可能在细胞分化和炎症中起作用。YKL-40在患有炎症性疾病或癌症的患者的血清中升高,目前正在作为这些疾病的潜在生物标志物进行研究。
观测分子量〜42 kDa

Immunogen

对应于人几丁质酶-3样蛋白1(YKL-40)的重组蛋白。

Other Notes

浓度:关于批次特定浓度请参见检验报告。

Physical form

形式:纯化
纯化的小鼠单克隆IgG1κ,溶于不含防腐剂的PBS缓冲液中。
纯化蛋白G

Preparation Note

自接收之日起,在-20°C下可稳定保存1年。
处理建议: 收到后,在取下瓶盖之前,将小瓶离心并轻轻混合溶液。分装至微量离心管中,并储存于-20°C。避免反复冻融循环,否则可能损坏IgG并影响产品性能。

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存储类别

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable


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