MABC592
抗-TRP1/TYRP1抗体（克隆TA99，不含叠氮化物）
clone TA99, 1 mg/mL, from mouse
别名:
5,6-dihydroxyindole-2-carboxylic acid oxidase, DHICA oxidase, Catalase B, Glycoprotein 75, Melanoma antigen gp75, Tyrosinase-related protein 1, TRP, TRP-1, TRP1
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
TA99, monoclonal
Application:
blocking
flow cytometry
immunohistochemistry
immunoprecipitation (IP)
western blot
flow cytometry
immunohistochemistry
immunoprecipitation (IP)
western blot
Species reactivity:
human, mouse
Citations:
9
Technique(s):
blocking: suitable (interfering antibodies)
flow cytometry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
flow cytometry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
Uniprot accession no.:
产品名称
抗-TRP1/TYRP1抗体（克隆TA99，不含叠氮化物）, clone TA99, 1 mg/mL, from mouse
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
TA99, monoclonal
species reactivity
human, mouse
concentration
1 mg/mL
technique(s)
blocking: suitable (interfering antibodies)
flow cytometry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable
isotype
IgG2aκ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... TYRP1(7306)
Analysis Note
通过蛋白质印迹在小鼠皮肤组织裂解物中进行了评估。
蛋白质印迹分析：1 µg/mL的该抗体在10 µg小鼠皮肤组织裂解物中检测到RP1/TYRP1。
蛋白质印迹分析：1 µg/mL的该抗体在10 µg小鼠皮肤组织裂解物中检测到RP1/TYRP1。
Application
免疫组化分析：一个代表批次的 1:50 稀释液在人黑素瘤组织中检测到TRP1/TYRP1。
干扰抗体阻滞分析：一个来自独立实验室的代表性批次抑制皮下B16 肿瘤生长（Patel, D., et al. (2008).Anticancer Res. 28(5A):2679-2686.）。
活性分析：一个来自独立实验室的代表性批次通过增强针对肿瘤细胞的全身性CD8+T细胞反应，改善了抗肿瘤效力（Saenger, Y. M., et al. (2008).Cancer Res. 68(23):9884-9891.)。
免疫沉淀分析：一个来自独立实验室的代表性批次对B16细胞裂解液的TRP1/TYRP1进行了免疫沉淀（Srinivasan, R., et al. (2002).Cancer Immun.19(2):8.）。
干扰抗体阻滞分析：一个来自独立实验室的代表性批次抑制皮下B16 肿瘤生长（Patel, D., et al. (2008).Anticancer Res. 28(5A):2679-2686.）。
活性分析：一个来自独立实验室的代表性批次通过增强针对肿瘤细胞的全身性CD8+T细胞反应，改善了抗肿瘤效力（Saenger, Y. M., et al. (2008).Cancer Res. 68(23):9884-9891.)。
免疫沉淀分析：一个来自独立实验室的代表性批次对B16细胞裂解液的TRP1/TYRP1进行了免疫沉淀（Srinivasan, R., et al. (2002).Cancer Immun.19(2):8.）。
研究子类别
凋亡-附加
凋亡-附加
研究类别
细胞凋亡 & 癌症
细胞凋亡 & 癌症
该抗-TRP1/TYRP1抗体（克隆TA99，不含叠氮化物）经验证可用于蛋白质印迹、IHC、干扰抗体阻滞（blocking of inteferring antibodies）、IP &、流式细胞术检测TRP1/TYRP1。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
TRP1/TYRP1，也称5,6-二羟基吲哚-2-羧酸氧化酶、DHICA、过氧化氢酶B、糖蛋白75、黑色素瘤抗原gp75或酪氨酸酶相关蛋白1（TRP/TRP-1/TRP1），由TYRP1/CAS2/TYRP/TYRRP基因编码，它涉及合成，并且是将DHICA 氧化为吲哚-5,6-醌-2-羧酸的酶。TRP1/TYRP1对于皮肤/眼睛/头发的色素沉着很关键。突变与白化病有关。TRP1/TYRP1 是由小眼畸形相关转录因子（MITF）调节。MITF是色素沉着的主调节因子，也是黑素细胞分化过程中Wnt/β-连环蛋白信号传导中β-连环蛋白的靶点。TRP1/TYRP1也由microRNA miR-145调节，研究人员正在探索将microRNA用作色素沉着过度的可能疗法。在色素细胞的核内体和黑素体中，TRP1/TYRP1表达为膜蛋白。
观测值〜60 kDa
Immunogen
对应于人TRP1/TYRP1的全细胞。
Physical form
形式：纯化
纯化的小鼠单克隆IgG2aκ，溶于不含防腐剂的PBS缓冲液中。
蛋白G纯化
Preparation Note
自收到之日起在-20°C可稳定保存1年。
使用建议：收货后，在取下瓶盖之前，将小瓶离心并轻轻混合溶液。分装到微量离心管中，并储存于-20°C。避免反复冻融循环，以免损坏IgG和影响产品性能。
使用建议：收货后，在取下瓶盖之前，将小瓶离心并轻轻混合溶液。分装到微量离心管中，并储存于-20°C。避免反复冻融循环，以免损坏IgG和影响产品性能。
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存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
C L Slingluff et al.
Cancer immunology, immunotherapy : CII, 48(12), 661-672 (2001-02-07)
Melanoma-reactive HLA-A x 0201-restricted cytotoxic T lymphocyte (CTL) lines generated in vitro lyse autologous and HLA-matched allogeneic melanoma cells and recognize multiple shared peptide antigens from tyrosinase, MART-1, and Pme117/gp100. However, a subset of melanomas fail to be lysed by
Ling Jiang et al.
Journal of cellular physiology, 234(12), 22799-22808 (2019-05-23)
Our previous study found that Ganoderma lucidum polysaccharide (GLP), bioactive ingredients from Ganoderma lucidum, protected fibroblasts from photoaging. However, whether GLP can affect melanogenesis in melanocytes through regulating paracrine mediators that secreted by keratinocytes and fibroblasts is unclear. We aimed
Shiyao Pei et al.
The Journal of investigative dermatology, 140(1), 152-163 (2019-07-06)
The long noncoding RNA UCA1 was first discovered in bladder cancer and is known to regulate the proliferation and migration of melanoma. However, its role in melanogenesis is unclear. In this study, we aimed to explore the role and mechanism
Shuanghai Hu et al.
Journal of cellular physiology, 234(5), 7330-7340 (2018-10-27)
Ultraviolet (UV)-induced pigmentation is very common in clinical practice, but the current treatments are rarely effective, accompanied by some side effects. Ganoderma lucidum polysaccharide (GLP) is a natural antioxidant with no toxic side effects, which can antagonize UVB-induced fibroblast photo
Li-Ping Liu et al.
Cell reports, 27(2), 455-466 (2019-04-11)
Induced pluripotent stem cells (iPSCs) are a promising melanocyte source as they propagate indefinitely and can be established from patients. However, the in vivo functions of human iPSC-derived melanocytes (hiMels) remain unknown. Here, we generated hiMels from vitiligo patients using a three-dimensional
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