MABC95
抗-S1PR2/EDG5抗体，克隆6E8.1
clone 6E8.1, from mouse
别名:
Sphingosine 1-phosphate receptor 2, S1P receptor 2, S1P2, Endothelial differentiation G-protein coupled receptor 5, Sphingosine 1-phosphate receptor Edg-5, S1P receptor Edg-5
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
6E8.1, monoclonal
Application:
IHC, WB
Species reactivity:
human
Citations:
2
Technique(s):
immunohistochemistry: suitable (paraffin), western blot: suitable
Uniprot accession no.:
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
6E8.1, monoclonal
species reactivity
human
technique(s)
immunohistochemistry: suitable (paraffin), western blot: suitable
isotype
IgMκ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Quality Level
Gene Information
human ... S1PR2(9294)
Analysis Note
已通过蛋白质印迹法在人体肝脏组织裂解液中进行了评估。
蛋白质印迹分析：1 µg/mL该抗体在10 g人肝脏组织裂解物中检测到S1PR2/EDG5。
蛋白质印迹分析：1 µg/mL该抗体在10 g人肝脏组织裂解物中检测到S1PR2/EDG5。
Application
免疫组化分析：代表性批次在人扁桃体、肝脏、结直肠癌组织中检测到S1PR2/EDG5。
抗-S1PR2/EDG5抗体，克隆6E8.1可检测S1PR2/EDG5水平，已发布，经验证可用于蛋白质印迹、IHC(P)。
Biochem/physiol Actions
该抗体可识别S1PR2/EDG5的胞质结构域。
General description
可观察到约35 kDa的条带
鞘氨醇1-磷酸受体2（S1PR2），也称EDG5，是一种普遍存在的溶鞘脂鞘氨醇1-磷酸（S1P）G蛋白偶联受体。它与Gi、G12/13和Gq通路偶联，可调节许多第二信使和效应分子，包括cAMP、PLC、MAPK、RhoA和Rac。S1PR2介导S1P对细胞运动和胚胎发育以及其他细胞过程的影响。
Immunogen
GST标记的重组蛋白，对应于人S1PR2/EDG5的胞质域。
Other Notes
浓度：请参考批次特异性浓缩物的检验报告。
Physical form
形式：纯化
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存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
T H Beckham et al.
Oncogenesis, 2, e49-e49 (2013-06-05)
Acid ceramidase (AC) is overexpressed in most prostate tumors and confers oncogenic phenotypes to prostate cancer cells. AC modulates the cellular balance between ceramide, sphingosine and sphingosine 1-phosphate (S1P). These bioactive sphingolipids have diverse, powerful and often oppositional impacts on
Xiao-Jing Sun et al.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 32(8), 1313-1322 (2017-02-17)
C5a plays a crucial role in anti-neutrophil cytoplasmic antibody (ANCA)-mediated neutrophil recruitment and activation. Our previous studies found that the interaction between sphingosine-1-phosphate (S1P) and C5a plays an important role in the ANCA-mediated activation of neutrophils. In the current study
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